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| Sodium ketoisocaproate Basic information |
| Product Name: | Sodium ketoisocaproate |
| Synonyms: | Sodium ketoisocaproate;SODIUM 4-METHYL-2-OXOVALERATE;SODIUM ALPHA-KETOISOCAPRATE;2-KETOISOCAPROIC ACID SODIUM SALT;2-KETOISOHEXANOIC ACID SODIUM SALT;A-KETOISOCAPROIC ACID, SODIUM SALT;ALPHA-KETOISOCAPROIC ACID SODIUM SALT;4-Methyl-2-oxopentanoic acid monosodium salt |
| CAS: | 4502-00-5 |
| MF: | C6H9NaO3 |
| MW: | 152.12 |
| EINECS: | 224-816-3 |
| Product Categories: | pharmacetical |
| Mol File: | 4502-00-5.mol |
| Sodium ketoisocaproate Chemical Properties |
| Melting point | 275 °C (dec.)(lit.) |
| storage temp. | 2-8°C |
| JECFA Number | 633.1 |
| BRN | 4239297 |
| CAS DataBase Reference | 4502-00-5(CAS DataBase Reference) |
| Safety Information |
| Safety Statements | 24/25-22 |
| WGK Germany | 3 |
| MSDS Information |
| Provider | Language |
|---|---|
| 4-Methyl-2-oxopentanoic acid sodium salt | English |
| SigmaAldrich | English |
| ACROS | English |
| Sodium ketoisocaproate Usage And Synthesis |
| Occurrence | Reported found in banana, asparagus, cheese, white wine, a, blue cheese and provolone cheese. |
| Uses | Sodium 4-methyl-2-oxovalerate has been used for quantifying branched-chain keto acids from cell extracts by HPLC-fluorescence method. |
| Uses | 4-Methyl-2-oxovaleric Acid is an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an intermediate in the metabolism of Leucine. |
| Biochem/physiol Actions | α-Ketoisocaproic acid is a leucine metabolite that is known to induce insulin secretion from the βcells of pancreas. Enteral infusion of aα-Ketoisocaproate is found to ameliorate, endotoxemic condition. The resulting ketone bodies obtained from its conversion, might serve as an energy source. Accumulation of α-Ketoisocaproic acid is characterized in branched chain ketoaciduria, which is caused due to the lack of branched chain L-2-keto acid dehydrogenase activity. α-Ketoisocaproic acid causes dissociation in the oxidative phosphorylation reaction and acts as a metabolic inhibitor of α-ketoglutarate dehydrogenase. Thus, leads to a defect in the mitochondrial homeostasis, observed in branched chain ketoaciduria. |
| Sodium ketoisocaproate Preparation Products And Raw materials |