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Adenosine 5'-monophosphate monohydrate Basic information |
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Adenosine 5'-monophosphate monohydrate Chemical Properties |
Hazard Codes |
Xi |
Risk Statements |
36/37/38 |
Safety Statements |
26-36 |
WGK Germany |
3 |
RTECS |
AU7480500 |
F |
8-10-21 |
TSCA |
Yes |
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Adenosine 5'-monophosphate monohydrate Usage And Synthesis |
Chemical Properties |
White crystalline powder |
Uses |
Nutrient;Ca++ channel block |
Purification Methods |
The acid has been recrystallised from H2O (fine needles) and is freely soluble in boiling H2O. It crystallises also from H2O on addition of . Alternatively purify it by chromatography on Dowex 1 (in formate form), eluting with 0.25M formic acid. It is then adsorbed onto charcoal (which had been boiled for 15minutes with M HCl, washed free of chloride and dried at 100o) and recovered by stirring three times with isoamyl alcohol/H2O (1:9 v/v). The aqueous layer from the combined extracts is evaporated to dryness under reduced pressure, and the product is crystallised twice from hot H2O. [Morrison & Doherty Biochem J 79 433 1961]. It has max 259nm ( 15,400) in H2O at pH 7.0. [Alberty et al. J Biol Chem 193 425 1951, Martell & Schwarzenbach Helv Chim Acta 39 653 1956]. The acridinium salt has m 208o [Baddiley & Todd J Chem Soc 648 1947, Pettit Synthetic Nucleotides, van Nostrand-Reinhold, NY, Vol 1 252 1972, NMR: Sarma et al. J Am Chem Soc 96 7337 1974, Norton et al. J Am Chem Soc 98 1007 1976, IR of diNa salt: Miles Biochem Biophys Acta 27 324 1958]. [Beilstein 26 III/IV 3615.] |
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Adenosine 5'-monophosphate monohydrate Preparation Products And Raw materials
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