Choline dihydrogencitrate salt Basic information |
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Choline dihydrogencitrate salt Chemical Properties |
Hazard Codes |
Xi |
Risk Statements |
36/37/38 |
Safety Statements |
26 |
WGK Germany |
2 |
RTECS |
GA2582000 |
HS Code |
29231000 |
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Choline dihydrogencitrate salt Usage And Synthesis |
Chemical Properties |
White crystalline powder |
Originator |
Chothyn, Flint, US,1945 |
Manufacturing Process |
30 lb of trim were added to 70.4 lb of methyl alcohol to which 9.2 lb of water had previously been added. To the resulting solution in a closed vessel 23 lb of ethylene oxide gas were introduced and the resulting mixture then maintained at a temperature of 16 C to 30 C and agitated for 6 hours. During the reaction the pressure in the reaction vessel varied from about 17.5 psi at the start of the reaction to 0 psi at the end of the reaction. The resulting solution was then added with agitation to a refluxing solution of 40 liters of isopropyl alcohol containing 95 lb of citric acid dissolved therein. This mixture was then cooled to 0°C and held at that temperature overnight. The white crystalline choline dihydrogen citrate which formed was separated from the solvent mixture by filtration and dried in vacuo. 117 lb of anhydrous, crystalline choline dihydrogen citrate having a purity of 99.6% were obtained. This was a yield of 78% based on the amount of trim employed. |
Therapeutic Function |
Lipotropic |
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Choline dihydrogencitrate salt Preparation Products And Raw materials |
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