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Largest Manufacturer Supply D-Panthenol CAS 81-13-0 For stock delivery

Largest Manufacturer Supply D-Panthenol CAS 81-13-0 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

Largest Manufacturer Supply D-Panthenol CAS 81-13-0 For stock delivery

Dexpanthenol Basic information
Description References
Product Name: Dexpanthenol
Synonyms: 4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(theta)-butanamid;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-d-(+)-butyramid;Alcopan-250;Bepanthen;Bepanthene;Bepantol;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-
CAS: 81-13-0
MF: C9H19NO4
MW: 205.25
EINECS: 201-327-3
Product Categories: Inhibitors;haircare cosmetics;Pharmaceutical Intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;ILOPAN
Mol File: 81-13-0.mol
Dexpanthenol Structure
 
Dexpanthenol Chemical Properties
Melting point 64~69℃
alpha 30.5 º (c=5, H2O on anh. sub)
Boiling point 118-120 °C (2.7 mmHg)
density 1.20 g/mL at 20 °C(lit.)
refractive index 1.495-1.502
Fp 118-120°C/0.02m
storage temp. −20°C
pka 13.03±0.20(Predicted)
form Viscous Liquid or Semi Solid
color Clear colorless to slightly yellow
PH pH (100g/l,25℃) : 8.5~10.5
optical activity [α]20/D +30±1°, c = 5% in H2O
Water Solubility soluble
Sensitive Hygroscopic
Merck 14,2947
BRN 1724947
InChIKey SNPLKNRPJHDVJA-ZETCQYMHSA-N
CAS DataBase Reference 81-13-0(CAS DataBase Reference)
NIST Chemistry Reference Dexpanthenol(81-13-0)
EPA Substance Registry System (+)-Panthenol (81-13-0)
 
Safety Information
Hazard Codes Xn
Risk Statements 36/37/38-48-41-37/38-20/21/22
Safety Statements 23-24/25-45-36/37/39-26-22
WGK Germany 1
RTECS ES4316000
F 3-10
TSCA Yes
HS Code 29241990
Hazardous Substances Data 81-13-0(Hazardous Substances Data)
Toxicity LD50 oral in mouse: 15gm/kg
MSDS Information
Provider Language
(+)-Panthenol English
SigmaAldrich English
ACROS English
ALFA English
 
Dexpanthenol Usage And Synthesis
Description Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.
References https://pubchem.ncbi.nlm.nih.gov/compound/Dexpanthenol#section=Top
https://www.drugs.com/pro/dexpanthenol.html
https://de.wikipedia.org/wiki/Dexpanthenol
Chemical Properties clear colorless to slightly yellow viscous liquid
Originator Bepanthene,Roche,France,1951
Uses cholinergic
Uses D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol.
Uses immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic
Manufacturing Process 130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid lactone are dissolved in 150 parts by volume of methyl alcohol. 75 parts by weight of 3-hydroxypropylamine are added, in one portion, to the solution and the mixture is well stirred. While the reaction sets in, the temperature of the mixture gradually rises by itself to about 50°C and then drops again after about two hours. To cause completion of the reaction, the mixture is allowed to stand at room temperature for 24 hours. The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from methyl alcohol in vacuo. It is a colorless, viscous oil, easily soluble in water. It boils under a pressure of 0.02 mm between 118° and 120°C.
Brand name D-Panthenol 50 (BASF); Ilopan (Savage); Motilyn (Abbott).
Therapeutic Function Gastrointestinal drug
Contact allergens Pan(to)thenol is the alcohol corresponding to pantothenic acid, of the vitamin B5 group. It is used as a food additive, and in skin and hair products as a conditioning agent. Contact dermatitis and urticaria have been reported.
Safety Profile Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES.
Veterinary Drugs and Treatments Dexpanthenol has been suggested for use in intestinal atony or distension, postoperative retention of flatus and feces, prophylaxis and treatment of paralytic ileus after abdominal surgery or traumatic injuries, equine colic (not due to mechanical obstruction) and any other condition when there is an impairment of smooth muscle function. Controlled studies are lacking with regard to proving the efficacy of the drug for any of these indications.
Purification Methods Purify D-panthenol by distillation in vacuo. It is a slightly hygroscopic viscous oil and is soluble in H2O and organic solvents. It is hydrolysed by alkali and strong acid. [Rabin J Am Pharm Assoc (Sci Ed) 37 502 1948, Bonati & Pitré Farmaco Ed Scient 14 43 1959, Beilstein 4 IV 1652.]
 
Dexpanthenol Preparation Products And Raw materials
Raw materials 3-Aminopropanol