| beta-Nicotinamide adenine dinucleotide disodium salt Basic information |
| Product Name: |
beta-Nicotinamide adenine dinucleotide disodium salt |
| Synonyms: |
eta-d-ribofuranosyl-3-pyridinecarboxamide,disodiumsalt;BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE, REDUCED FORM DISODIUM SALT;BETA-NICOTINAMIDE-ADENINE DINUCLEOTIDE, REDUCED, 2NA;BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED DISODIUM SALT;BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE, DISODIUM SALT;beta-Nicotinamide adenine dinucleotidedisodium salthydrate;eta-d-ribofuranosyl-3-pyridinecarboxamide, disodium salt beta-nicotinamide adenine dinucleotide, disodium salt, hydrate beta-nicotinamide adenine dinucleotide disodium salt,trihydrate;NICOTINAMIDE ADENINE DINUCLEOTIDE (REDUCED) DISODIUM SALT extrapure |
| CAS: |
606-68-8 |
| MF: |
C21H30N7NaO14P2 |
| MW: |
689.44 |
| EINECS: |
210-123-3 |
| Product Categories: |
Bases & Related Reagents;Carbohydrates & Derivatives;Cofactors and SubstratesBiochemicals and Reagents;Nucleotides;Phosphorylating and Phosphitylating Agents;nucleoside;NAD and AnalogsResearch Essentials;Nucleosides and NucleotidesEnzymes, Inhibitors, and Substrates;Oxidation-ReductionMetabolic Pathways;Core Bioreagents;Electron Transport and Cellular Respiration;Metabolic Pathways;Metabolites and Cofactors on the Metabolic Pathways Chart;TCA;Bioproducts;Cofactor;Oxidation-Reduction;Cofactors;Enzymes, Inhibitors, and Substrates;Biochemicals and Reagents;NAD and Analogs;Nucleosides, Nucleotides, Oligonucleotides |
| Mol File: |
606-68-8.mol |
 |
| |
| beta-Nicotinamide adenine dinucleotide disodium salt Chemical Properties |
| Melting point |
140-142°C |
| storage temp. |
2-8°C |
| solubility |
H2O: 50 mg/mL, clear to nearly clear, yellow |
| form |
Powder |
| color |
Yellow |
| PH |
7.5 (100mg/mL in water, ±0.5) |
| Water Solubility |
soluble |
| BRN |
5230241 |
| Stability: |
Stable. Incompatible with strong oxidizing agents. |
| InChIKey |
QRGNQKGQENGQSE-WUEGHLCSSA-L |
| CAS DataBase Reference |
606-68-8 |
| EPA Substance Registry System |
Reduced .beta.-nicotinamide adenine dinucleotide disodium salt (606-68-8) |
| |
| beta-Nicotinamide adenine dinucleotide disodium salt Usage And Synthesis |
| Chemical Properties |
beige powder |
| Uses |
One of the biologically active forms of nicotinic acid. Serves as a coenzyme of hydrogenases and dehydrogenases. NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen d onor in the respiratory chain. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Occurs in 2 forms, α-NAD and β-NAD, distinguished by the configura tion of the ribosyl nicotinamide linkage. Only the β-anomer is bioactive. |
| Definition |
A dehydrogenase complex that is the reduced formof NAD. |
| Purification Methods |
This coenzyme is available in high purity, and it is advisable to buy a fresh preparation rather than to purify an old sample as purification will invariably lead to a more impure sample contaminated with the oxidised form (NAD). It has UV max at 340nm ( 6,200 M-1cm-1) at which wavelength the oxidised form NAD has no absorption. At 340nm a 0.161mM solution in a 1cm (pathlength) cell has an absorbance of 1.0 unit. The purity is best checked by the ratio A280nm/A340nm ~2.1, a value which increases as oxidation proceeds. The dry powder is stable indefinitely at -20o. Solutions in aqueous buffers at pH ~7 are stable for extended periods at -20o and for at least 8hours at 0o, but are oxidised more rapidly at 4o in a cold room (e.g. almost completely oxidised overnight at 4o). [UV: Drabkin J Biol Chem 175 563 1945, Fluorescence: Boyer & Thorell Acta Chem Scand 10 447 1956, Redox: Rodkey J Biol Chem 234 188 1959, Schlenk in The Enzymes 2 250, 268 1951, Kaplan in The Enzymes 3 105, 112 1960.] Deuterated NADH, i.e. NADD, has been purified through the anion exchange resin AG-1 x 8 (100-200 mesh, formate form) and through a Bio-Gel P-2 column. [Viola et al. Anal Biochem 96 334 1979, Beilstein 26 III/IV 3639.] |
| |
| beta-Nicotinamide adenine dinucleotide disodium salt Preparation Products And Raw materials |
|
