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China Largest Factory Manufacturer N-Acetyl-D-Glucosamine(NAG) CAS 7512-17-6  For stock delivery

China Largest Factory Manufacturer N-Acetyl-D-Glucosamine(NAG) CAS 7512-17-6 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Largest Factory Manufacturer N-Acetyl-D-Glucosamine(NAG) CAS 7512-17-6 For stock delivery

N-Acetyl-D-Glucosamine Basic information
Product Name: N-Acetyl-D-Glucosamine
Synonyms: N-Acetyl-D-glucosaMine, 98.0%(LC&N;N-qcetyl-D-glucosamine;2-Acetamido-2-deoxy-alpga-D-glucopyranose;D-GLCNAC;ACETYL-D-GLUCOSAMINE, N-;N-ACETYL-DELTA-GLUCOSAMINE;2-ACETAMIDO-2-DESOXY-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE;2-ACETAMIDO-2-DEOXY-D-GLUCOSE
CAS: 7512-17-6
MF: C8H15NO6
MW: 221.21
EINECS: 231-368-2
Product Categories: Carbohydrate Matrices;Affinity Chromatography;Dextrins,Sugar & Carbohydrates;aldehydes;Carbohydrates & Derivatives;Protein Chromatography;13C & 2H Sugars;Aminosugars;Biochemistry;Glucose;Sugars;Biological and chemical;amino
Mol File: 7512-17-6.mol
N-Acetyl-D-Glucosamine Structure
 
N-Acetyl-D-Glucosamine Chemical Properties
Melting point 211 °C (dec.)(lit.)
alpha 42 º (c=2,water,2 hrs)
refractive index 40.5 ° (C=1, H2O)
storage temp. 2-8°C
solubility H2O: 50 mg/mL colorless to faint yellow solution, clear to very slightly hazy
pKa 13.04±0.20(Predicted)
Boiling point 636.4±55.0 °C(Predicted)
density 1.54 g/cm3
form saline suspension
color white to off-white
Water Solubility Soluble in concentrated hydrochloric acid, sulfuric acid, phosphoric acid and formic acid. Insoluble in water, dilute acids, dilute alkalis, concentrated alkalis and organic solvents.
Sensitive Hygroscopic
Merck 14,4458
BRN 1727589
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey OVRNDRQMDRJTHS-ROGOILFBSA-N
CAS DataBase Reference 7512-17-6(CAS DataBase Reference)
EPA Substance Registry System N-Acetylglucosamine (7512-17-6)
 
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-36-26-22
WGK Germany 3
RTECS LZ6651000
F 3-10
Hazard Note Irritant
TSCA Yes
HS Code 29329985
MSDS Information
Provider Language
SigmaAldrich English
ALFA English
 
N-Acetyl-D-Glucosamine Usage And Synthesis
Description N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate.
N-Acetyl-D-glucosamine (D-GlcNAc) is a derivitized glucose monomer found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. It is also synthesized in the glycosylation pathway as uridine diphosphate (UDP-GlcNAc), which can then be released following degradation of glycosylated proteins.D-GlcNAc is used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s). It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
Chemical Properties White powder
Uses A pharmaceutical and cosmetic compound.
Uses N-acetyl-D-Glucosamine (GlcNAc) is a monosaccharide derivative of glucose. It is released by the action of O-GlcNAcase, in mammalian systems from proteins that have been post-translationally modified with O-GlcNAc. Levels of O-GlcNAcylation proteins from Alzheimer’s disease brain extracts are decreased as compared to that in controls, suggesting that release of GlcNAc may contribute to pathogenesis.1 In E. coli, GlcNAc induces the expression of multidrug exporter genes, indicating that this sugar can alter gene expression.1 GlcNAc is also the monomeric unit of chitin, which is found in fungi and many invertebrates, including crustaceans, insects, and nematodes. For this reason, chemicals that inhibit the incorporation of GlcNAc into chitin are cytotoxic to these organisms.
  1. Atypical microbial danger signal that acts as a new activator of NLRP3 inflammasome by dissociating the enzyme hexokinase from the mitochondria. D-GlcNAc inhibits purified hexokinase, which is also involved in the glucose metabolism and obesity in mM range. For hexokinase dissociation from the mitochondria much higher concentrations are needed.
  2. Acceptor substrate for galactosyltransferases. Inhibits the lectin WGA and is used to identify, differentiate and characterize N-acetyl-β-D-hexosaminidase(s).
  3. Used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Significantly enhances the prevention of joint damage and inhibits elastase activity and superoxide release from human polymorphonuclear leukocytes. Acts as a cytoprotective agent restoring the integrity and normal function of mucous membrane in humans.
  4. D-GlcNAc enhances the proliferation and collagen expression of fibroblasts, reduces hyperpigmentation and is therefore considered a valuable ingredient in cosmetics for improving skin wrinkles and color.
  5. Important substrate for the production of sialic acids.
  6. Used in multiple other applications in drug development and food supplement, based on a newly described bio-wave model.
Definition ChEBI: The pyranose form of N-acetyl-D-glucosamine.
 
N-Acetyl-D-Glucosamine Preparation Products And Raw materials