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China Largest Factory Manufacturer Denatonium Benzoate CAS 3734-33-6 For stock delivery

China Largest Factory Manufacturer Denatonium Benzoate CAS 3734-33-6 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Largest Factory Manufacturer Denatonium Benzoate CAS 3734-33-6 For stock delivery

Denatonium Benzoate Anhydrous Basic information
The most bitter compound in the world Chemical structure Uses
Product Name: Denatonium Benzoate Anhydrous
Synonyms: N,N-DIETHYL-N-[(2,6-DIMETHYLPHENYLCAR-BAMOYL)METHYL]BENZYLAMMONIUM BENZOATE;N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]-N,N-diethyl-benzenemethanaminium benzoate;REJEXIT (R);benzyldiethyl (2,6-xylylcarbamoylmethyl)-ammonium;Bitrex? Denatonium Benzoate;Denatoniumbenzoate,96%;Acetylthio-2-Methylpro-Panoyl Chloride;DenatoniumBenzoate,Granular,Usp
CAS: 3734-33-6
MF: C28H34N2O3
MW: 446.58
EINECS: 223-095-2
Product Categories: DIMETANE;Miscellaneous Biochemicals;Ammonium Polyhalides, etc. (Quaternary);Quaternary Ammonium Compounds
Mol File: 3734-33-6.mol
Denatonium Benzoate Anhydrous Structure
 
Denatonium Benzoate Anhydrous Chemical Properties
Melting point 164-168 °C(lit.)
Boiling point 555.91°C (rough estimate)
density 1.1256 (rough estimate)
refractive index 1.5800 (estimate)
Fp 100℃
solubility methanol: 50 mg/mL, clear, colorless
Merck 14,2891
BRN 8179408
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey VWTINHYPRWEBQY-UHFFFAOYSA-N
CAS DataBase Reference 3734-33-6(CAS DataBase Reference)
EPA Substance Registry System Denatonium benzoate (3734-33-6)
 
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38-20/21/22
Safety Statements 26-36-37/39
WGK Germany 2
RTECS BO6650000
TSCA Yes
HS Code 29242995
MSDS Information
 
Denatonium Benzoate Anhydrous Usage And Synthesis
The most bitter compound in the world Denatonium benzoate is now known as the world's most bitter compound. If we set the bitter degree of quinine as datum 1, the degree of bitterness of the product would be 1000. A concentration of 10ppm solution is already too bitter to bear for most people. The vast majority of its applications are related to its bitter flavor. It is an inexpensive and efficient alternative to its counterparts such as strychnine, bitter lignin, quinine, wood song glycosides, saponins grapefruit.
Denatonium benzoate is commonly used as aversive agent to prevent people from eating other toxic but tasteless substance. For example, it has been added into industrial alcohol, ethylene glycol or methanol which has similar taste as ordinary wine, antifreeze, paint, toilet cleaners, animals disperse, liquid soaps and shampoos. Moreover, it has been also added into special nail polish agents, to avoid child’s bad habit of biting fingers, as well as being the repellent for expulsing large beasts. However, the effect of Long-term exposure to this substance on human health is still unclear.
Chemical structure Denatonium benzoate is a kind of quaternary ammonium salt formed by the combination of the quaternary ammonium cation and inert anion such as benzoic acid or saccharin anion. The structure of its cation form is similar to that of a local anesthetic lidocaine with the only difference being an additional benzyl functional group located on the nitrogen atom of the amino.
Uses Flavoring agent.
Chemical Properties white crystals
Chemical Properties Denatonium benzoate occurs as an odorless, very bitter tasting, white crystalline powder or granules.
Uses H1 antihistamine
Uses Pharmaceutic aid (alcohol denaturant; flavor). Added to toxic substances as a deterrent to accidental ingestion. Can replace brucine or quassin as denaturant for ethyl alcohol.
Production Methods Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate.
Brand name Bitrex (Mac Farlan Smith, Scotland).
Pharmaceutical Applications Denatonium benzoate is among the most bitter of substances known and is detectable at concentrations of approximately 10 ppb. In pharmaceutical and other industrial applications it is added to some products as a deterrent to accidental ingestion. It is most commonly used at levels of 5–500 ppm. Denatonium benzoate may also be used to replace brucine or quassin as a denaturant for ethanol.
In pharmaceutical formulations, denatonium benzoate has been used as a flavoring agent in placebo tablets, and in a topical formulation it has been used in an anti-nailbiting preparation.
Safety Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,therehasbeenasinglereportof contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate.
LD50 (rabbit, oral): 0.508g/kg
LD50 (rat, oral): 0.584g/kg
storage Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light.
Incompatibilities Denatonium benzoateis incompatible with strongoxidizing agents.
Regulatory Status Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution).
 
Denatonium Benzoate Anhydrous Preparation Products And Raw materials