Retinyl acetate Basic information |
Product Name: | Retinyl acetate |
Synonyms: | RETINYL ACETATE;RETINOL ACETATE;RETINOL ACETATE ALL TRANS;RETINOL ACETATE, WATER SOLUBLE;VITAMIN A ACETATE, ALL TRANS;VITAMIN A ACETATE 1500;VITAMIN A ACETATE;TRANS-RETINOL ACETATE |
CAS: | 127-47-9 |
MF: | C22H32O2 |
MW: | 328.49 |
EINECS: | 204-844-2 |
Product Categories: | Vitamin series;Retinoids;Vitamins and derivatives;Vitamin Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors |
Mol File: | 127-47-9.mol |
Retinyl acetate Chemical Properties |
Melting point | 57-58 °C |
Boiling point | 406.22°C (rough estimate) |
density | 1.0474 (rough estimate) |
refractive index | 1.547-1.555 |
Fp | 14℃ |
storage temp. | 2-8°C |
solubility | absolute ethanol: 25 mg/mL |
form | solid or viscous liquid |
color | Yellow powder |
Odor | Amine like |
Water Solubility | soluble |
Sensitive | Light & Air Sensitive & Hygroscopic |
Merck | 14,10013 |
BRN | 1915439 |
InChIKey | QGNJRVVDBSJHIZ-QHLGVNSISA-N |
CAS DataBase Reference | 127-47-9(CAS DataBase Reference) |
NIST Chemistry Reference | Retinol, acetate(127-47-9) |
EPA Substance Registry System | Retinol acetate (127-47-9) |
Safety Information |
Hazard Codes | Xn,Xi,T,F |
Risk Statements | 38-63-36/37/38-53-61-11 |
Safety Statements | 36/37-45-37/39-26-53-16 |
RIDADR | UN1170 - class 3 - PG 2 - Ethanol |
WGK Germany | 2 |
RTECS | VH6825000 |
F | 1-8-10 |
TSCA | Yes |
HS Code | 29362100 |
Toxicity | LD50 (10 day) orally in mice: 4100 mg/kg (Kamm) |
MSDS Information |
Provider | Language |
---|---|
all-trans Vitamin A acetate | English |
ACROS | English |
SigmaAldrich | English |
ALFA | English |
Retinyl acetate Usage And Synthesis |
Description | Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent. |
Reference | Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5 |
Chemical Properties | Crystalline |
Uses | vitamin precursor |
Uses | Essential micronutrient |
Safety Profile | Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A. |
Purification Methods | The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.] |