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China Northwest Factory Manufacturer Alpha Ketoglutaric Acid(AKG) Cas 328-50-7 For stock delivery

China Northwest Factory Manufacturer Alpha Ketoglutaric Acid(AKG) Cas 328-50-7 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Northwest Factory Manufacturer Alpha Ketoglutaric Acid(AKG) Cas 328-50-7 For stock delivery

2-Ketoglutaric acid Basic information
Description References
Product Name: 2-Ketoglutaric acid
Synonyms: 2-KETOGLUTARIC ACID;2-OXOGLUTARIC ACID;2-OXOPENTANEDIOIC ACID;A-KETOGLUTARIC ACID;Glutaric acid, 2-oxo-;Glutaric acid, alpha keto;-Ketoglutaricacid;α-Ketoglutaricacid
CAS: 328-50-7
MF: C5H6O5
MW: 146.1
EINECS: 206-330-3
Product Categories: Nutrition;food additives;Pharmaceutical Intermediates;Aliphatics;Organic acids;pharm raw material;Amino Acids;Food Additives
Mol File: 328-50-7.mol
2-Ketoglutaric acid Structure
 
2-Ketoglutaric acid Chemical Properties
Melting point 113-115 °C
Boiling point 185.67°C (rough estimate)
density 1.2821 (rough estimate)
FEMA 3891 | 2-OXOPENTANEDIOIC ACID
refractive index 1.3920 (estimate)
storage temp. 2-8°C
solubility H2O: soluble0.1g/mL, clear, colorless
pka 2.47(at 25℃)
form Crystalline Powder
color White to slightly yellow
Odor Odorless
Water Solubility Soluble in water, methanol and dimethyl sulfoxide.
Merck 14,5303
JECFA Number 634
BRN 1705689
InChIKey KPGXRSRHYNQIFN-UHFFFAOYSA-N
CAS DataBase Reference 328-50-7(CAS DataBase Reference)
NIST Chemistry Reference 2-Oxopentanedioic acid(328-50-7)
EPA Substance Registry System Pentanedioic acid, 2-oxo- (328-50-7)
 
Safety Information
Hazard Codes Xi,T
Risk Statements 37/38-41-36/37/38-23/24/25
Safety Statements 26-39-45-36/37/39
WGK Germany 3
TSCA Yes
HS Code 29183000
MSDS Information
Provider Language
alpha-Ketoglutaric acid English
SigmaAldrich English
ACROS English
ALFA English
 
2-Ketoglutaric acid Usage And Synthesis
Description 2-Ketoglutaric acid also known as α-Ketoglutaric acid (AKG) is a chemical found in the body. It is a ketone derivative of the organic compound glutaric acid. It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid or Krebs cycle. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles, and kidneys, as well as help balance the body’s nitrogen chemistry and prevent nitrogen excess in body tissues and fluids.
α-Ketoglutaric acid is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.
References [1] http://www.webmd.com
[2] https://en.wikipedia.org/wiki/Alpha-Ketoglutaric_acid
Chemical Properties Crystalline
Uses A derivative of glutaric acid.
Definition ChEBI: An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle.
Biotechnological Applications a-Ketoglutaric acid is an intermediate of the tricarboxylic acid cycle and the main compound of amino acid and protein metabolism. This organic acid could be used as building-block chemical for the chemical synthesis of heterocycles, dietary supplement, component of infusion solutions, and wound healing compounds (Otto et al. 2013).
Thiamine deficiency is a critical factor in the formation of a-ketoglutaric acid by Y. lipolytica. The yeast strain is unable to synthesize the pyrimidine structure of the thiamine molecule, or a medium with thiamine deficiency required for production of a-ketoglutaric acid. The a-ketoglutaric acid excretion was triggered after logarithmic growth phase when the yeast was grown on a medium containing hexadecane or other alkanes with low thiamine concentration (0.7 lg/L). The biosynthesis of the acid continued in the stationary phase. It was possible to increase the concentration of a-ketoglutaric acid to 108.7 g/L on petrolatum with a substrate-related yield of 120 % (Finogenova et al. 2005).
The hyper-producing strain H355 produced highest amounts of a-ketoglutaric acid up to 195 g/L with a mixture of n-paraffins (C12–C18). Vegetable oils (olive, canola, sunflower, linseed, and rapeseed oil), ethanol, and glycerol were used as substrate for production of a-ketoglutaric acid by Y. lipolytica (Chernyavskaya et al. 1997, 2000; Il’chenko et al. 2001, 2002, 2003; Finogenova et al. 2002; Otto et al. 2013; Kamzolova and Morgunov 2013).
The effects of different conditions on production a-ketoglutaric acid, including initial substrate concentration, nitrogen source, exogenous vitamins, and calcium carbonate are investigated in some studies. The influence of thiamine limitation and excess of carbon and nitrogen source as well as a low pH on the intensive aketoglutaric acid production are revealed in the previous work. Thiamine and calcium ion concentration had the greatest effect on this organic acid accumulation when glycerol was used as carbon source (Zhou et al. 2010). An increased amount of zinc and iron ions is required for the a-ketoglutaric acid production from ethanol (Kamzolova et al. 2012a).
Purification Methods Crystallise the keto-acid repeatedly from Me2CO/*benzene, EtOAc or ethyl propionate. Dry it in vacuo.[Beilstein 3 IV 1813.]