|Polaprezinc Basic information|
|Synonyms:||POLAPREZINC;zinc l-carnosine complex;zinc n-(3-aminopropionyl)histidine;ZINC CARNOSINE;[b-Alanyl-kN-L-histidinato(2-)-kN,kO]-zinc;b-Alanyl-L-histidinato Zinc;Promac;Z 103|
|Product Categories:||Intermediates & Fine Chemicals;Pharmaceuticals|
|Polaprezinc Chemical Properties|
|CAS DataBase Reference||107667-60-7(CAS DataBase Reference)|
|Toxicity||LD50 in male, female mice, rats (mg/kg): 220, 165, 405, 422 i.p.; 758, 874, >5000, >5000 s.c.; 1269, 1331, 8441, 7375 orally (Matsuda)|
|Polaprezinc Usage And Synthesis|
|Description||Polaprezinc, a complex of zinc ion and L-carnosine, is an antiulcer agent launched in Japan. It is effective in promoting the healing of gastric ulcers in addition to preventing ulcer relapse. In rat studies, polaprezinc reduces the incidence of stomach lesions induced by ethanol. No effect was seen on ultrastructural damage or on cell proliferation and it appears that polaprezinc combines the cytoprotective effect of zinc with the ulcer healing properties of Lcarnosine. The in vivo antioxidative properties of polaprezinc has been suggested to be responsible for its protective effect against gastric mucosal injury.
Recent studies revealed that polaprezinc is an activator of bone formetion and has inhibitory effect of bone resorption. This agent is thus able to prevent the deterioration of bone metabolism indicating its potential usefulness in the treatment of osteoporosis. Polaprezinc has also been claimed for the prophylaxis and treatment of alcoholic hepatopathy, viral hepatitis or other hepatopathies caused by certain drugs, poisons and radiation.
|Chemical Properties||White To Pale-Yellow Crystalline Solid|
|Uses||A novel anti-gastric ulcer agent|
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|Uses||anti-ulcer drug, antioxidative,|