Leader Biochemical Group 86--029-68895030 info@leader-biogroup.com
China Northwest Factory Manufacturer NONIVAMIDE(NVA) Cas 2444-46-4 For stock delivery

China Northwest Factory Manufacturer NONIVAMIDE(NVA) Cas 2444-46-4 For stock delivery

  • Color
    White
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    USD300-600KG
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Northwest Factory Manufacturer NONIVAMIDE(NVA) Cas 2444-46-4 For stock delivery

Nonivamide Basic information
Description References
Product Name: Nonivamide
Synonyms: Nonivamide(Synthetic Capsaicin);N-((Hydroxy-3-phenyl)methyl)4-nonanamide;N-Nonanoyl vanillylamide;Nonanamide, N-((4-hydroxy-3-phenyl)meth;SYNTHETIC CAPSAICIN;PELARGONYL VANILLYLAMIDE;PELARGONIC ACID VANILLYLAMIDE;N-PELARGONIC ACID VANILLYLAMIDE
CAS: 2444-46-4
MF: C17H27NO3
MW: 293.4
EINECS: 219-484-1
Product Categories: Anilines, Aromatic Amines and Nitro Compounds;INORGANIC & ORGANIC CHEMICALS;Plant extract;Herb extract;Inhibitors;API
Mol File: 2444-46-4.mol
Nonivamide Structure
 
Nonivamide Chemical Properties
Melting point 54°C
Boiling point 200-210 °C(Press: 0.05 Torr)
density 1,1 g/cm3
FEMA 2787 | NONANOYL 4-HYDROXY-3-BENZYLAMIDE
Fp 190°C
storage temp. 2-8°C
solubility methanol: 100 mg/mL, clear to slightly hazy
pka 9.76±0.20(Predicted)
form powder
color white to off-white
JECFA Number 1599
BRN 2144300
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey RGOVYLWUIBMPGK-UHFFFAOYSA-N
CAS DataBase Reference 2444-46-4(CAS DataBase Reference)
EPA Substance Registry System Nonanamide, N-[(4-hydroxy-3-phenyl)methyl]- (2444-46-4)
 
Safety Information
Hazard Codes T,Xi
Risk Statements 25-36/37/38-43
Safety Statements 26-45-37/39-36/37
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS RA5998000
F 19
HazardClass 6.1
PackingGroup II
HS Code 29242990
MSDS Information
Provider Language
SigmaAldrich English
 
Nonivamide Usage And Synthesis
Description Nonivamide is also called pelargonic acid vanillylamide or PAVA. It is a capsaicinoid. Nonivamide, isolated from peppers, is a naturally occurring analog of capsaicin (sc-3577). Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. Nonivamide is with lower TRPV1 binding affinity, thus, a reduced pungency (9 200 000 scoville heat units) compared to capsaicin (16 000 000 scoville heat units).
Nonivamide is used in the food production to add a hot sensation to flavoring agents and spice mixtures. It is also used in the sweets and confectionary industries to add hot sensation into products. In pharmaceutical industries, nonivamide is used as a cheaper alternative for capsaicin. Warming or heating ointment of nonivamide is used for temporary relief of pain from conditions such as rheumatism, arthritis, lumbao, muscular aches, sprains and strains, sporting injuries and other conditions where local warmth is beneficial. Finalgon is one of the common product utilizing nonivamide for this purpose. Nonivamide is also used as an incapacitant spray, affecting the assailed person’s eyes, causing intense pain and swelling.
References [1] https://www.scbt.com/scbt/product/nonivamide-2444-46-4
[2] https://pubchem.ncbi.nlm.nih.gov/compound/N-Vanillylnonanamide#section=Clinical-Trials
[3] https://cot.food.gov.uk/sites/default/files/cot/cotsection.pdf
Description Nonanoyl-4-hydroxy-3-benzylamide is odorless with a pungent, burning taste. Synthesized from nonanyl chloride and vanillylamine.
Chemical Properties n-Nonanyl-4-hydroxy-3-benzyl-amide is an odorless compound, but has a pungent, burning taste
Chemical Properties solid
Uses analgesic (topical), depletes Substance P
Uses N-Vanillylnonanamide is a synthetic analogue of Capsaicin (175680) with similar bioactivity.
Definition ChEBI: A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-benzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.
Preparation From nonanyl chloride and vanillylamine.