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n-Docosanol Basic information

Product Name:	n-Docosanol
Synonyms:	ALCOHOL C22;BEHENYLIC ALCOHOL;Behenic alcohol;behenicalcohol;Cachalot BE-22;Dehydag wax 22 (lanette);Docosan-1-ol;Docosanol-(1)
CAS:	661-19-8
MF:	C22H46O
MW:	326.6
EINECS:	211-546-6
Product Categories:	ABREVA;Pharmaceutical Raw Materials;Saturated Higher Alcohols;1-Alkanols;Antivirals for Research and Experimental Use;Biochemistry;Higher Fatty Acids & Higher Alcohols;Monofunctional & alpha,omega-Bifunctional Alkanes;Monofunctional Alkanes;Pharma material;fine chemicals;Inhibitors
Mol File:	661-19-8.mol

n-Docosanol Chemical Properties

Melting point	65-72 °C(lit.)
Boiling point	180 °C0.22 mm Hg(lit.)
density	d75 0.8063 g/ml; d85 0.7986 g/ml; d95 0.7911 g/ml
refractive index	n75 1.4360
storage temp.	2-8°C
pka	15.20±0.10(Predicted)
form	Pellets or Tablets
color	White
Water Solubility	Insoluble
Merck	13,3433
BRN	1770470
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	661-19-8(CAS DataBase Reference)
NIST Chemistry Reference	1-Docosanol(661-19-8)
EPA Substance Registry System	1-Docosanol (661-19-8)

Safety Information

Safety Statements	24/25
WGK Germany	-
RTECS	JR1315000
TSCA	Yes
HS Code	29051900
Hazardous Substances Data	661-19-8(Hazardous Substances Data)
Toxicity	LD50 intraperitoneal in mouse: > 800mg/kg

MSDS Information

Provider	Language
1-Docosanol	English
ACROS	English
SigmaAldrich	English
ALFA	English

n-Docosanol Usage And Synthesis

Chemical Properties	1-DOCOSANOL is white powder
Uses	antiviral
Uses	n-Docosanol is a binder and an emulsion stabilizer. It is also used to increase a formulation’s viscosity. This is a mixture of fatty alcohols. behenyl alcohol may be used for any number of purposes in a cosmetic formulation, including as an emollient, a binder, an emulsion stabilizer, or to increase a product’s viscosity. It may be derived either synthetically or from plants.
Definition	1-DOCOSANOL is a long-chain, saturated fatty alcohol.
Indications	Docosanol (Abreva) is a long-chain saturated alcohol that is clinically effective against HSV. It has in vitro activity against many enveloped viruses, including CMV, influenzavirus, and respiratory syncytial virus. Docosanol is not directly virucidal; instead, it blocks the entry of the virion into the host cell by inhibiting the fusion of the viral envelope with the host plasma membrane. Because it does not affect viral replication or protein production, it may be less susceptible to the development of resistance than other antiviral drugs.
Pharmaceutical Applications	1-DOCOSANOL is a 22-carbon straight chain alcohol licensed for over-thecounter sales for the topical treatment of herpes labialis. It is thought to act by blocking viral fusion with the host cell, although definitive studies are lacking. The clinical relevance of the antiviral activity has been debated and the place of this medication as a treatment of herpes labialis remains to be established.
Clinical Use	Docosanol cream is approved for the over-the-counter treatment of herpes labialis. It shortens the duration of symptoms of cold sores and fever blisters but does not provide symptomatic relief.
Side effects	Adverse effects of docosanol are minimal. Skin irritation occurs infrequently. Drug interactions are not anticipated.
Purification Methods	Crystallise docosanol from r or chloroform/r. [Beilstein 1 IV 1906.]

n-Docosanol Preparation Products And Raw materials

Preparation Products

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