The World Largest Manufacturer Factory Supply D-ERYTHRO-SPHINGOSINE CAS 123-78-4

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D-ERYTHRO-SPHINGOSINE Basic information Product Name: D-ERYTHRO-SPHINGOSINE Synonyms: SPHINGOSINE;SPHINGOSINE, C18 CHAIN;SPHINGOSINE, D-ERYTHRO;TRANS D-THREO-SPHINGOSINE;TRANS D-ERYTHRO-SPHINGOSINE;TRANS-D-ERYTHRO-2-AMINO-4-OCTADECENE-1,3-DIOL;BRAIN SPHINGOSINE;BRAIN, BOVINE CAS: 123-78-4 MF: C18H37NO2 MW: 299.49 EINECS: 204-651-3 Product Categories: Amines;Protein Kinase;Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators Mol File: 123-78-4.mol   D-ERYTHRO-SPHINGOSINE Chemical Properties Melting point 74.2-78.1 °C Boiling point 440.8°C (rough estimate) density 0.9758 (rough estimate) refractive index 1.5000 (estimate) storage temp. −20°C solubility chloroform: 20 mg/mL, clear, colorless to very faintly yellow form Powder or Waxy Solid pka 11.80±0.45(Predicted) color White to cream Merck 14,8747 BRN 1727294 Stability: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents. InChIKey WWUZIQQURGPMPG-KRWOKUGFSA-N CAS DataBase Reference 123-78-4   Safety Information Safety Statements 22-24/25 WGK Germany 3 F 1-8-10 HS Code 29221985 MSDS Information Provider Language ACROS English SigmaAldrich English   D-ERYTHRO-SPHINGOSINE Usage And Synthesis Chemical Properties White Crystalline Solid Uses Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine Definition cerebroside: Any one of a class ofglycolipids in which a single sugarunit is bound to a sphingolipid. The most commoncerebrosides are galactocerebrosides,containing the sugar group galactose;they are found in the plasma membranesof neural tissue and are abundantin the myelin sheaths ofneurones. Biological Activity Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C. Purification Methods D-Sphingosine is purified by recrystallisation from EtOAc, Et2O or pet r (60-80o). It is insoluble in H2O but is soluble in Me2CO, EtOH and MeOH. It has IR bands at 1590 and 875 cm-1, and is characterised as the tribenzoate m 122-123o (from 95% EtOH). [Tipton Biochemical Preparations 9 127 1962.]   D-ERYTHRO-SPHINGOSINE Preparation Products And Raw materials