Steviol glycosides are intensely sweet plant-derived compounds permitted to be added to a wide variety of foods and beverages. An extensive toxicological database on steviol glycosides has been evaluated by several government authorities who concluded that there is no evidence of genotoxicity, carcinogenicity, or reproductive/developmental toxicity. An ADI of 0–4 mg kg−1 bw has been established from laboratory animal studies by the JECFA. Clinical trials in human volunteers have demonstrated the safety of steviol glycosides at levels corresponding to the upper end of the ADI range. Some dietary exposure assessment scenarios have resulted in predicted exposures that exceed the ADI; however, assuming a 30% market uptake scenario of steviol glycosides, the highest predicted exposure is within the ADI.