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Google Factory Sales Highest Quality Guaifenesin CAS 93-14-1 For stock delivery

Google Factory Sales Highest Quality Guaifenesin CAS 93-14-1 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    info@leader-biogroup.com
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

Google Factory Sales Highest Quality Guaifenesin CAS 93-14-1 For stock delivery

Guaifenesin Basic information
Description References
Product Name: Guaifenesin
Synonyms: 1,2-Dihydroxy-3-(2-phenoxy)propane;1,2-Propanediol, 3-(2-phenoxy)-;1,2-Propanediol, 3-(o-phenoxy)-;2/G;2-G;3-(2-phenosy)-1,2-propamediol;3-(2-phenoxy)-2-propanediol;3-(o-phenoxy)-2-propanediol
CAS: 93-14-1
MF: C10H14O4
MW: 198.22
EINECS: 202-222-5
Product Categories: Building Blocks;C10;Chemical Synthesis;rs;Organic Building Blocks;Oxygen Compounds;Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Methocarbamol;API;MUCINEX;Benzhydrols, Benzyl & Special Alcohols
Mol File: 93-14-1.mol
Guaifenesin Structure
 
Guaifenesin Chemical Properties
Melting point 77-81 °C
Boiling point 215 °C (19 mmHg)
density 1.1825 (rough estimate)
refractive index 1.5550 (estimate)
Fp 215°C/19mm
storage temp. Refrigerator
solubility 50g/l (experimental)
form neat
pka 13.53±0.20(Predicted)
Water Solubility 5 g/100 mL (25 ºC)
Merck 14,4555
BRN 2049375
InChIKey HSRJKNPTNIJEKV-UHFFFAOYSA-N
CAS DataBase Reference 93-14-1(CAS DataBase Reference)
NIST Chemistry Reference 3-(O-phenoxy)-1,2-propanediol(93-14-1)
EPA Substance Registry System Guaifenesin (93-14-1)
 
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 1
RTECS TY8400000
Hazard Note Harmful
TSCA Yes
HS Code 29093090
Hazardous Substances Data 93-14-1(Hazardous Substances Data)
Toxicity LD50 oral in rabbit: 2553mg/kg
MSDS Information
Provider Language
ACROS English
SigmaAldrich English
ALFA English
 
Guaifenesin Usage And Synthesis
Description Guaifenesin is an oral expectorant drug. The expectorant action of guaifenesin is mediated by stimulation of the gastrointestinal tract. It is a common ingredient in prescription and over-the-counter medications used to treat cough due to colds and minor upper respiratory infections.
References [1] Peter V. Dicpinigaitis and Yvonne E. Gayle, Effect of Guaifenesin on Cough Reflex Sensitivity, 2003, vol. 124, 2178-2181
[2] Leonid Kagan, Eran Lavy and Ammon Hoffmann, Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model, Pulmonary Pharmacology & Therapeutics, 2009, vol. 22, 260-265
Chemical Properties White Solid
Originator GG Cen,Central,US,1975
Uses Centrally acting muscle relaxant with expectorant properties
Uses Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
Manufacturing Process A mixture of o-phenol (57 g), glycidol (32 g) and pyridine (1 g) is warmed to 95°C at which temperature a vigorous reaction takes place. The reaction mixture is cooled to prevent the temperature rising above 110°C. When the exothermic reaction has subsided the reactants are heated at 95°C for one hour longer and then distilled under low pressure. The main fraction boils in the range 176°C to 180°C/0.5 mm. It crystallizes on cooling. Recrystallization from benzene gives the pure product, MP 78.5°C to 79.0°C.
Brand name Mucinex (Adams).
Therapeutic Function Expectorant
Mechanism of action Guaiphenesin facilitates secretion from bronchial mucous membranes, thus relieving a cough in colds, bronchitis, and bronchial asthma.
Chemical Synthesis Guaiphenesin, 3-(o-phenoxy)-1,2-propandiol (23.2.3), is synthesized by reacting guiacol with 3-chloropropan-1,2-diol or with glycidol.

Google Factory Sales Highest Quality Guaifenesin CAS 93-14-1 For stock delivery 1

Veterinary Drugs and Treatments In veterinary medicine, guaifenesin is used to induce muscle relaxation and restraint as an adjunct to anesthesia for short procedures (30 – 60 minutes) in large and small animal species. There are combination oral products containing guaifenesin for treating respiratory conditions in horses.
In human medicine, guaifenesin has long been touted as an oral expectorant, but definitive proof of its efficacy is lacking.
 
Guaifenesin Preparation Products And Raw materials
Raw materials Ammonium hydroxide-->Diethyl carbonate-->Guaiacol-->3-Chloro-1,2-propanediol-->Glycidol
Preparation Products Zinc oxide-->Lithopone-->Zinc nitrate hexahydrate-->Methocarbamol