| 2-Aminothiazole Basic information |
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| 2-Aminothiazole Chemical Properties |
| Melting point |
91-93 °C (lit.) |
| Boiling point |
117 °C (15.002 mmHg) |
| density |
1.241 (estimate) |
| vapor pressure |
<1 hPa (20 °C) |
| refractive index |
1.5300 (estimate) |
| Fp |
117°C/15mm |
| storage temp. |
Hormones |
| solubility |
1 M HCl: soluble50mg/mL, clear (dark yellow-brown) |
| pka |
5.36(at 20℃) |
| form |
Crystalline Powder, Grains, Lumps or Flakes |
| color |
Brown |
| PH |
9.6 (100g/l, H2O, 20℃) |
| Water Solubility |
100 g/L (20 ºC) |
| Merck |
14,479 |
| BRN |
105738 |
| InChIKey |
RAIPHJJURHTUIC-UHFFFAOYSA-N |
| CAS DataBase Reference |
96-50-4(CAS DataBase Reference) |
| NIST Chemistry Reference |
2-Aminothiazole(96-50-4) |
| EPA Substance Registry System |
2-Aminothiazole (96-50-4) |
| Hazard Codes |
Xn,Xi |
| Risk Statements |
22-36-36/37-20/21/22 |
| Safety Statements |
26-36/37-39-36 |
| RIDADR |
2811 |
| WGK Germany |
3 |
| RTECS |
XJ2100000 |
| F |
8-9 |
| Autoignition Temperature |
600 °C |
| Hazard Note |
Irritant |
| TSCA |
Yes |
| HS Code |
29341000 |
| Toxicity |
LD50 orally in Rabbit: 480 mg/kg |
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| 2-Aminothiazole Usage And Synthesis |
| Chemical Properties |
brown crystalline powder, grains, lumps or flakes |
| Uses |
antithyroid agent |
| Uses |
2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds. |
| Uses |
Usually used in the synthesis of 2-aminothiazole-modified silica gel,and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation. |
| Definition |
ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2. |
| Synthesis Reference(s) |
Journal of the American Chemical Society, 76, p. 693, 1954 DOI: 10.1021/ja01632a016 |
| General Description |
Light brown crystals or brown granular solid. |
| Air & Water Reactions |
Insoluble in water. |
| Reactivity Profile |
2-Aminothiazole reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-Aminothiazole is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. |
| Fire Hazard |
Flash point data for 2-Aminothiazole are not available; however, 2-Aminothiazole is probably combustible. |
| Safety Profile |
Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi |
| Purification Methods |
It crystallises from pet r (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.] |
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| 2-Aminothiazole Preparation Products And Raw materials |
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