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China Manufacturer Sales Highest Quality ALPHA-CYCLODEXTRIN CAS 10016-20-3 For stock delivery

China Manufacturer Sales Highest Quality ALPHA-CYCLODEXTRIN CAS 10016-20-3 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Manufacturer Sales Highest Quality ALPHA-CYCLODEXTRIN CAS 10016-20-3 For stock delivery

Cyclohexapentylose Basic information
Product Name: Cyclohexapentylose
Synonyms: SCHARDINGER ALPHA-DEXTRIN;ALPHA-CYCLODEXTRIN;CYCLOHEXAAMYLOSE;CYCLOMALTOHEXAOSE;CYCLOMALTOHEXOSE;2,4,7,9,12,14,17,19,22,24,27,29-Dodecaoxaheptacyclo(26.2.2.23,6.28,11.213,16.218,21.223,26)dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol, 5,10,15,20,25,30-hexakis(hydroxymethyl)-;Alfadex;alpha-Cycloamylose
CAS: 10016-20-3
MF: C36 H60 O30
MW: 972.84
EINECS: 233-007-4
Product Categories: Industrial/Fine Chemicals;Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Dextrins,Sugar & Carbohydrates
Mol File: 10016-20-3.mol
Cyclohexapentylose Structure
 
Cyclohexapentylose Chemical Properties
Melting point >278 °C (dec.) (lit.)
alpha [α]D25 +146~+151° (c=1, H2O) (After Drying)
Boiling point 784.04°C (rough estimate)
density 1.2580 (rough estimate)
refractive index 1.7500 (estimate)
storage temp. Store at RT.
solubility H2O: 50 mg/mL
pka 11.77±0.70(Predicted)
form powder
color White
PH 5.0-8.0 (1% in solution)
optical activity [α]20/D +136±3°, c = 10% in H2O
Water Solubility Soluble in water at 1%(w/v)
Merck 14,2718
BRN 4227442
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey HFHDHCJBZVLPGP-RWMJIURBSA-N
CAS DataBase Reference 10016-20-3
NIST Chemistry Reference «alpha»-Cyclodextrin(10016-20-3)
EPA Substance Registry System .alpha.-Cyclodextrin (10016-20-3)
 
Safety Information
Hazard Codes Xi
Risk Statements 36-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS GU2292000
TSCA Yes
HS Code 29400090
MSDS Information
Provider Language
alpha-Cyclodextrin English
SigmaAldrich English
 
Cyclohexapentylose Usage And Synthesis
Chemical Properties White crystalline powder
Chemical Properties Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.
Uses also available in pharma grade
Uses A naturally occuring clathrate.
Production Methods Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.
General Description Hexagonal plates or blade-shaped needles.
Reactivity Profile Cyclohexapentylose has hydrophobic cavities. Cyclohexapentylose forms inclusion compounds with organic substances, salts, and halogens in the solid state or in aqueous solutions. Cyclohexapentylose is incompatible with strong oxidizing agents.
Fire Hazard Flash point data for Cyclohexapentylose are not available; however, Cyclohexapentylose is probably combustible.
Pharmaceutical Applications Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.
Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material.
a-Cyclodextrin is used mainly in parenteral formulations. However, as it has the smallest cavity of the cyclodextrins it can form inclusion complexes with only relatively few, small-sized molecules. In contrast, g-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules; it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as cortico. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.
Safety Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.
Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
α-Cyclodextrin
LD50 (rat, IP): 1.0 g/kg(15)
LD50 (rat, IV): 0.79 g/kg
storage Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.
Purification Methods Recrystallise α-cyclodextrin from 60% aqueous EtOH, then twice from water, and dry it for 12hours in a vacuum at 80o. It is also purified by precipitation from water with 1,1,2-trichloroethylene. The precipitate is collected, washed and resuspended in water. This is boiled to steam distil the trichloroethylene. The solution is then freeze-dried to recover the cyclodextrin. [Armstrong et al. J Am Chem Soc 108 1418 1986]. [Beilstein 19/12 V 789.]
Regulatory Status Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).
Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.
 
Cyclohexapentylose Preparation Products And Raw materials
Raw materials Dextrin-->BETA-CYCLODEXTRIN-->Superoxide dismutase