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| LIQUIRITIGENIN Chemical Properties |
| Melting point |
206-208°C |
| Boiling point |
529.5±50.0 °C(Predicted) |
| density |
1.386±0.06 g/cm3(Predicted) |
| Fp |
207℃ |
| pka |
7.71±0.40(Predicted) |
| BRN |
359378 |
| InChIKey |
FURUXTVZLHCCNA-AWEZNQCLSA-N |
| WGK Germany |
3 |
| HS Code |
29329990 |
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| LIQUIRITIGENIN Usage And Synthesis |
| Description |
Liquiritigenin is an active estrogenic component in extracts of Glycyrrhizae radix. Glycyrrhizae radix (G. radix, licorice, liquorice) is frequently used for life-enhancing properties, for the treatment of injury or swelling, for detoxification in traditional Oriental medicine, as well as a food supplement in many of the countries in the world. Liquiritigenin is a selective estrogen receptor-β (ERβ) agonist. Liquiritigenin activates multiple ER regulatory elements and native target genes with ERβ but not ERα. The ERβ-selectivity of liquiritigenin is due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes.
As the targeting ERβ is associated with anti-inflammatory effects, liquiritigenin exerts anti-inflammatory effects. Liquiritigenin is also reported to antihyperlipidemic, antiallergic and antihepatocellular carcinoma effects. |
| References |
[1] J. E. Mersereau, N. Levy, R. E. Staub, S. Baggett, T. Zogric, S. Chow, W. A. Ricke, M. Tagliaferri, I. Cohen, L. F. Bjeldanes (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist, Molecular and Cellular Endocrinology, 283, 49-57
[2] Di Wang, Jiahui Lu, Yan Liu, Qingfan Meng, Jing Xie, Zhenzuo Wang,Lesheng Teng (2014) Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells, BioMed Research International, 2014, Article ID 965316 |
| Definition |
ChEBI: A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta. |
| Purification Methods |
It crystallises from aqueous 50% EtOH. [Beilstein 18 III/IV 1780, 18/4 V 82.] |
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| LIQUIRITIGENIN Preparation Products And Raw materials |
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