| Silibinin Basic information |
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| Silibinin Chemical Properties |
| Melting point |
164-174°C |
| alpha |
D20 +11° (c = 0.25 in + alcohol) |
| Boiling point |
793.0±60.0 °C(Predicted) |
| density |
1.527±0.06 g/cm3(Predicted) |
| storage temp. |
−20°C |
| pka |
pKa 6.42±0.04 (Uncertain) |
| Water Solubility |
54mg/L(24.99 ºC) |
| Merck |
13,8607 |
| Stability: |
Stable. Incompatible with strong oxidizing agents, strong bases. |
| CAS DataBase Reference |
22888-70-6(CAS DataBase Reference) |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38 |
| Safety Statements |
26-37/39-24/25-22-36 |
| RIDADR |
3172 |
| WGK Germany |
3 |
| RTECS |
DJ2981770 |
| HS Code |
29329990 |
| Toxicity |
LD50 intravenous in mouse: 1056mg/kg |
| |
| Silibinin Usage And Synthesis |
| Chemical Properties |
solid |
| Originator |
Legalon,Madaus,W. Germany,1969 |
| Uses |
Labelled Silybin (S465850). Hepatoprotectant. |
| Definition |
ChEBI: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. |
| Manufacturing Process |
Silymarin comprising polyhydroxyphenyl chromanones is recovered from the dried fruit of Silybum marianum Gaertn. by separating the fatty oils therefrom, extracting the remaining solid residue with ethyl acetate, evaporating the ethyl acetate and dissolving the dry residue in a solvent mixture comprising methanol, water and petroleum r to form a two-phase system wherein the chromanones are contained in the lower phase, recovering the polyhydroxyphenyl chromanones from the lower phase after subjecting same to multiple counter-current contact with petroleum r. |
| Therapeutic Function |
Hepatoprotectant |
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| Silibinin Preparation Products And Raw materials |
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