| L-Homophenylalanine Basic information |
| Description References |
| Product Name: | L-Homophenylalanine |
| Synonyms: | (+)-2-Amino-4-phenylbutyric acid,98%;S)-α-Amino-benzenebutanoic acid;L-(S)-Homophenylalanine.HCl;L-Homophenylalanine ,98%;H-L-HPA-OH;Benzenebutanoicacid, a-aMino-, (aS)-;H-HoMophe-OH(HoMophenylalanine);RARECHEM BK PT 0049 |
| CAS: | 943-73-7 |
| MF: | C10H13NO2 |
| MW: | 179.22 |
| EINECS: | 213-403-3 |
| Product Categories: | API intermediates;Homophenylalanine [Hph];Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Aromatics;Chiral Compounds;Phenylalanine analogs and other aromatic alpha amino acids;Chiral Compound;Amino Acids |
| Mol File: | 943-73-7.mol |
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| L-Homophenylalanine Chemical Properties |
| Melting point | >300 °C(lit.) |
| alpha | 45 º (C=1, 3N HCl 19 ºC) |
| Boiling point | 311.75°C (rough estimate) |
| density | 1.1248 (rough estimate) |
| refractive index | 44 ° (C=1, 3mol/L HCl) |
| storage temp. | Store at RT. |
| solubility | Soluble in dilute aqueous acid. |
| pka | 2.32±0.10(Predicted) |
| InChIKey | JTTHKOPSMAVJFE-VIFPVBQESA-N |
| CAS DataBase Reference | 943-73-7(CAS DataBase Reference) |
| MSDS Information |
| Provider | Language |
|---|---|
| (S)-alpha-Amino-benzenebutanoic acid | English |
| ACROS | English |
| SigmaAldrich | English |
| L-Homophenylalanine Usage And Synthesis |
| Description | L-Homophenylalanine is an amino acid derivative. It has been extensively used in the pharmaceutical industry as a precursor for production of angiotensin-converting enzyme (ACE) inhibitor: enalapril, delapril, quinapril and ramipril, which possesses significant clinical application in the management of hypertension and congestive heart failure (CHF). It acts as an anti-tumor reagent. |
| References | Hwang, J. Y., et al. "Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway." Biotechnology & Bioengineering 102.5(2009):1323-9. Ahmad, A. L., P. C. Oh, and S. R. Abd Shukor. "Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor."Biotechnology Advances 27.3(2009):286-296. https://www.alfa.com/en/catalog/H27295/ |
| Chemical Properties | White Solid |
| Uses | Antitumor agent. |
| Definition | ChEBI: A non-proteinogenic L-alpha-amino acid that is an analogue of L-phenylalanine having a 2-phenylethyl rather than a benzyl side-chain. |
| L-Homophenylalanine Preparation Products And Raw materials |