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China Largest Factory Manufacturer MALEIC ACID CAS 110-16-7 For stock delivery

China Largest Factory Manufacturer MALEIC ACID CAS 110-16-7 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Largest Factory Manufacturer MALEIC ACID CAS 110-16-7 For stock delivery

Maleic acid Basic information
Product Name: Maleic acid
Synonyms: (z)-butenedioicaci;1,2-Ethylenedicarboxylic acid, (Z);1,2-ethylenedicarboxylicacid,(z);2-Butenedioicacid(Z)-;acidemaleique;Butenedioic acid,(Z)-;cis-Ethylene-1,2-dicar-boxylicacid;Kyselina maleinova
CAS: 110-16-7
MF: C4H4O4
MW: 116.07
EINECS: 203-742-5
Product Categories: Used in synthetic resin and pesticide;Pharmaceutical intermediates;Building Blocks;C1 to C5;Carbonyl Compounds;Carboxylic Acids;Miscellaneous;Chemical Synthesis;Nutrition Research;Organic Building Blocks;Panax ginseng;Phytochemicals by Plant (Food/Spice/Herb);API Intermediate
Mol File: 110-16-7.mol
Maleic acid Structure
 
Maleic acid Chemical Properties
Melting point 137-140 °C(lit.)
Boiling point 275°C
density 1.59 g/mL at 25 °C(lit.)
refractive index 1.5260 (estimate)
Fp 127 °C
storage temp. Store at RT.
solubility 478.8g/l
pka 1.83(at 25℃)
form Powder/Solid
color White
Specific Gravity 1.59
PH 1.3 (100g/l, H2O, 20℃)
Water Solubility 790 g/L (25 ºC)
Merck 14,5703
BRN 605762
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, bases.
InChIKey VZCYOOQTPOCHFL-OWOJBTEDSA-N
CAS DataBase Reference 110-16-7(CAS DataBase Reference)
NIST Chemistry Reference 2-Butenedioic acid (Z)-(110-16-7)
EPA Substance Registry System Maleic acid (110-16-7)
 
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38-43
Safety Statements 26-28-37-28A-46-24
RIDADR 3261
WGK Germany 1
RTECS OM9625000
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29173990
Hazardous Substances Data 110-16-7(Hazardous Substances Data)
MSDS Information
Provider Language
SigmaAldrich English
ACROS English
ALFA English
 
Maleic acid Usage And Synthesis
Description Maleic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. Its chemical formula is HO2CCHCHCO2H. Maleic acid is the cis-isomer of butenedioic acid, where as fumaric acid is the trans-isomer. It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications.
Chemical Properties Maleic acid, HOOCCH:CHCOOH, also known as maleinic acid and toxilic acid,is a colorless crystalline dibasic acid. It is soluble in water and alcohol. Maleic acid is used in manufacturing synthetic resins, in textile processing, and in preserving oils and fats.
Chemical Properties Maleic acid is a white crystalline solid. Faint, acid like odor.
Chemical Properties Maleic acid occurs as a white crystalline (monoclinic) powder and possesses a faint acidulous odor and an astringent taste.
Fumaric acid and maleic acid are the simplest unsaturated carboxylic diacids. These acids experience two-step dissociation in aqueous solutions.They have the same structural formula but different spatial configurations. Fumaric acid is the trans and maleic acid the cis isomer. The physical properties of maleic acid and fumaric acid are very different. The cis isomer is less stable. Maleic acid is used in the preparation of fumaric acid by catalytic isomerization.
Physical properties Maleic acid is a less stable molecule than fumaric acid. The difference in heat of combustion is 22.7 kJ·mol?1. The heat of combustion is -1355 kJ / mole. Maleic acid is more soluble in water than fumaric acid. The melting point of maleic acid (135 °C) is also much lower than that of fumaric acid (287 °C). Both properties of maleic acid can be explained on account of the intramolecular hydrogen bonding that takes place in maleic acid at the expense of intermolecular interactions, and that are not possible in fumaric acid for geometric reasons.
Uses Maleic acid is an industrial raw material for the production of glyoxylic acid by ozonolysis.
Maleic acid may be used to form acid addition salts with drugs to make them more stable, such as indacaterol maleate.
Uses manufacture of artificial resins; to retard rancidity of fats and oils in 1:10,000 (these are said to keep 3 times longer than those without the acid); dyeing and finishing wool, cotton, and silk; preparing the maleate salts of antihistamines and similar drugs.
Definition ChEBI: A butenedioic acid in which the double bond has cis- (Z)-configuration.
Production Methods Maleic anhydride is the main source of maleic acid produced by hydration. Maleic anhydride is prepared commercially by the oxidation of benzene or by the reaction of butane with oxygen in the presence of a vanadium catalyst.
Reactions Although not practised commercially, maleic acid can be converted into maleic anhydride by dehydration, to malic acid by hydration, and to succinic acid by hydrogenation (ethanol / palladium on carbon). It reacts with thionyl chloride or phosphorus pentachloride to give the maleic acid chloride (it is not possible to isolate the mono acid chloride). Maleic acid, being electrophilic, participates as a dienophile in many Diels - Alder reactions.
Synthesis Reference(s) Journal of the American Chemical Society, 86, p. 4603, 1964 DOI: 10.1021/ja01075a017
The Journal of Organic Chemistry, 60, p. 6676, 1995 DOI: 10.1021/jo00126a013
Organic Syntheses, Coll. Vol. 2, p. 302, 1943
General Description Maleic acid is a colorless crystalline solid having a faint odor. Maleic acid is combustible though Maleic acid may take some effort to ignite. Maleic acid is soluble in water. Maleic acid is used to make other chemicals and for dyeing and finishing naturally occurring fibers.
Air & Water Reactions Soluble in water.
Reactivity Profile Maleic acid is a colorless to white crystalline solid. Moderately toxic. When heated to decomposition Maleic acid emits irritating fumes and acrid smoke [Lewis, 3rd ed., 1993, p. 790].
Hazard Toxic by ingestion.
Health Hazard Inhalation causes irritation of nose and throat. Contact with eyes or skin causes irritation.
Fire Hazard Special Hazards of Combustion Products: Irritating smoke containing maleic anhydride may form in fire.
Pharmaceutical Applications Maleic acid is used in the pharmaceutical industry as a pH modifier and a buffering agent.It is also used to prevent rancidity of oils and fats; a ratio of 1 : 10 000 is usually sufficient to retard rancidity. Maleic acid is commonly used as a pharmaceutical intermediate to form the maleate salts of several categories of therapeutic agents, such as salts of antihistamines and other drug substances.
Safety Profile Moderately toxic by ingestion and skin contact. Passes through intact skin. A skin and severe eye irritant and a corrosive. Believed to be more toxic than its isomer, fumeric acid. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Maleic acid is generally regarded as a nontoxic and nonirritant material when used at low levels as an excipient. Maleic acid is used in oral, topical, and parenteral pharmaceutical formulations in addition to food products.
LD50 (mouse, oral): 2.40g/kg(7)
LD50 (rabbit, skin): 1.56g/kg
LD50 (rat, oral): 0.708g/kg
Potential Exposure Maleic acid is used to make artificial resins, antihistamines, and to preserve (retard rancidity) of fats and oils
Carcinogenicity In chronic feeding studies, 12 Osborne–Mendel rats per group were fed 0.5, 1.0, or 1.5% maleic acid in their diets for 2 years. Concentrations of 1.0 and 1.5% maleic acid retarded the growth rate of rats, and all concentrations of maleic acid increased mortality rate; no tumorigenesis was reported. Toxicological differences from controls were not marked, and the pathology was nonspecific.
storage Maleic acid converts into the much higher-melting fumaric acid (mp: 287°C) when heated to a temperature slightly above its melting point.
Maleic acid is combustible when exposed to heat or flame. The bulk material should be stored in airtight glass containers and protected from light. It is recommended not to store it above 25°C.
Shipping UN2215 Maleic acid, Hazard class: 8; Labels: 8-Corrosive material.
Purification Methods Crystallise the acid from /pet r (b 60-80o) or hot water. Dry it at 100o. [Beilstein 2 H 748, 2 I 303, 2 II 641, 2 III 1911, 2 IV 2199.]
Incompatibilities Dust may form explosive mixture with air, Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, amines, reducing agents; alkali metals
Incompatibilities Maleic acid can react with oxidizing materials. Aqueous solutions are corrosive to carbon steels.
Waste Disposal Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Liquid: incinerate after mixing with a flammable solvent. Use afterburner for complete combustion. Solid: dissolve in a flammable solvent or package in paper and burn. See above
Regulatory Status Included in the FDA Inactive Ingredients Database (IM and IV injections; oral tablets and capsules; topical applications). Included in nonparenteral and parenteral medicines licensed in the UK.