| Application and Synthesis method |
Cosmetic polypeptides can penetrate the dermis to increase the level of collagen and reverse the aging process of the skin through rebuilding from inside to outside.
Cosmetic pentapeptide is also a cosmetic polypeptide. The prototype of the polypeptide is palmitic acid pentapeptide, commonly known as the five peptides, being able to simulate the paralysis effect of botulinum toxin. It is a short peptide fragment consisting of five amino acids formed by peptide bonds with its structure being similar to the protein. However, the protein has a longer peptide chain, usually consisting of hundreds of amino acids. Based on the differences of the number of amino acids, these polypeptides are divided into dipeptides (including two amino acids), tripeptides (including three amino acids), tetrapeptides (including four amino acids), etc. Because of the different categories of amino acids contained, both dipeptides and tripeptides have different varieties. At the same time, even with the same number of amino acids, the dipeptides will still have different varieties due to the different sort order of the amino acid. This leads to a number of peptides with a variety of roles and names. The pentapeptide is composed of six amino acids (Pal palmitic acid, Lys-lysine, Thr-threonine, Thr-threonine, Lys-lysine and Ser-serine).
The cosmetic pentapeptide is actually the C-terminal fragment of Collagen I, having an effect being similar to that of the laser surgery. It can stimulate the growth of collagen, stretch fibers and hyaluronic acid, improve skin moisture and the degree of locking water, increase skin thickness and reduce the microgroove; at the same time, addition of a long chain of fatty acids (palmitic acid) can increase the absorption effect. Compared with the laser surgery, the five-peptides is equivalent to intimate fusion with the skin, changing the skin ecology and cell repair, further playing the role of intracellular hormones and enzymes. |
| Uses |
palmitoyl pentapeptide-4 is a skin conditioner. Clinical studies by manufacturers credit it with an ability to promote collagen, elastin, and glycosaminoglycan synthesis. This would result in an ability to restore skin thickness, which diminishes with age, and to reduce the appearance of lines and wrinkles. Palmitoyl pentapeptide4 is a synthetic peptide with serine, threonine, and hexa decanoyl derivatives.
palmitoyl tetrapeptide-7 is formerly known as palmitoyl tetrapeptide3. This peptide appears to improve skin elasticity and firmness. It also hydrates, smoothes, and protects the skin. It can be both obtained from the plant and synthetically derived and is found in a variety of different skin care preparations including eye lotions, moisturizers, and night creams. Palmitoyl tetrapeptide3 appears to act as an anti-inflammatory. This is attributed to its ability to control the secretion of specific chemicals responsible for skin aging (i.e., cytokines and interleukin-6), and hence it may function in a manner similar to the anti-aging hormone, DHeA. Some studies indicate that palmitoyl tetrapeptide-7 may also act as a uV filter. |
