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China Largest Factory Manufacturer Fosfomycin Trometamol CAS 78964-85-9 For stock delivery

China Largest Factory Manufacturer Fosfomycin Trometamol CAS 78964-85-9 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Largest Factory Manufacturer Fosfomycin Trometamol CAS 78964-85-9 For stock delivery

Fosfomycin tromethamine Basic information
Product Name: Fosfomycin tromethamine
Synonyms: (3-methyloxiranyl)-phosphonicaci(2r-cis)-phosphonicacicompd.with2-amino-2-(hydroxy;fosfomycincompd.withtrometamol;fosfomycintrometamolsalt;methyl)-1,3-propanediol(1:1);Tromethamine fosfosmycin;Fosfomycin Tromethamine (800 mg);FosfoMycin troMethaMine API;Fosfomycin trometamolUSP, 98.0%-102.0%
CAS: 78964-85-9
MF: C7H18NO7P
MW: 259.19
EINECS: 279-018-8
Product Categories: API;Antibiotics
Mol File: 78964-85-9.mol
Fosfomycin tromethamine Structure
 
Fosfomycin tromethamine Chemical Properties
solubility Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in .
InChIKey QZJIMDIBFFHQDW-LMLSDSMGSA-N
 
Safety Information
HS Code 2941906000
MSDS Information
 
 
Fosfomycin tromethamine Usage And Synthesis
Chemical Properties White to off-white powder
Uses Phosphonic acid derivative; antibacterial.
Brand name Monurol (Zambon).
General Description Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.
 
Fosfomycin tromethamine Preparation Products And Raw materials