China Largest Factory Manufacturer N-Hydroxy succinimide/N-Hydroxysuccinimide CAS 6066-82-6 For stock delivery
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Purity99.9%
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UseHealth Care
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OriginChina
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Package1KG/Tin 25KG/Drum*Carton
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ManufacturerXI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
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Place of OriginCHINA
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Brand NameLeader
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CertificationISO,GMP,SGS,HALA,KOSER,HACCP
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Model NumberLD
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Minimum Order Quantity25KGS
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PriceNegotiate Depend on order quantity
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Packaging Details25KG/Drum
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Delivery Time2-3 working days
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Payment TermsWestern Union, MoneyGram, T/T, L/C
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Supply Ability10MTS/Month
China Largest Factory Manufacturer N-Hydroxy succinimide/N-Hydroxysuccinimide CAS 6066-82-6 For stock delivery
| N-Hydroxysuccinimide Basic information |
| Product Name: | N-Hydroxysuccinimide |
| Synonyms: | N-HYDROXY-2,5-PYRROLIDINEDIONE;NHS;N-HYDROXYSUCCINIMDE;N-HYDROXYSUCCINIMIDE;N-HYDROXYSUCCINIMIDE POLYMER-BOUND;NHS N-HYDROXYSUCCINIMIDE,;NHS OR HONSU;HOSu~1-Hydroxy-2,5-pyrrolidinedione |
| CAS: | 6066-82-6 |
| MF: | C4H5NO3 |
| MW: | 115.09 |
| EINECS: | 228-001-3 |
| Product Categories: | Zero-Length Crosslinker;heteroXlink;Coupling ReagentsSynthetic Reagents;Coupling;Others;APIS;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Succinimides;Peptide Synthesis;Supported Reagents;Supported Synthesis;Peptide coupling agents;Medical Intermediates;Heterocycles;Other Reagents;Miscellaneous Reagents;Synthetic Organic Chemistry |
| Mol File: | 6066-82-6.mol |
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| N-Hydroxysuccinimide Chemical Properties |
| Melting point | 95-98 °C(lit.) |
| Boiling point | 215.33°C (rough estimate) |
| density | 1.4769 (rough estimate) |
| refractive index | 1.4080 (estimate) |
| storage temp. | 2-8°C |
| pka | 7.81±0.20(Predicted) |
| form | Liquid or Solid |
| color | Clear yellow-brown to brown |
| PH | 5-7 (50g/l, H2O, 20℃) |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| BRN | 113913 |
| Stability: | Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture. |
| InChIKey | NQTADLQHYWFPDB-UHFFFAOYSA-N |
| CAS DataBase Reference | 6066-82-6(CAS DataBase Reference) |
| NIST Chemistry Reference | N-hydroxylsuccinimide(6066-82-6) |
| EPA Substance Registry System | 2,5-Pyrrolidinedione, 1-hydroxy- (6066-82-6) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-26-36 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29251995 |
| MSDS Information |
| Provider | Language |
|---|---|
| 1-Hydroxy-2,5-pyrrolidinedione | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| N-Hydroxysuccinimide Usage And Synthesis |
| Chemical Properties | White to pale yellow |
| Uses | Reagent for preparation of active esters of amino acids. |
| Uses | Useful in the carbodiimide method for improved amidations and peptide couplings. |
| Uses | Additive used in the carbodiimide method for improved amidations and peptide couplings. |
| Uses | N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide. |
| Purification Methods | Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.] |
| N-Hydroxysuccinimide Preparation Products And Raw materials |
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