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China Largest Factory Manufacturer L-VALINE  CAS 72-18-4 For stock delivery

China Largest Factory Manufacturer L-VALINE CAS 72-18-4 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Largest Factory Manufacturer L-VALINE CAS 72-18-4 For stock delivery

L-Valine Basic information
Amino acids Content Analysis Chemical property Uses
Product Name: L-Valine
Synonyms: (S)-alpha-Aminoisovaleric acid, (L)-2-Amino-3-methylbutanoic acid;Valine (V) Solution, 100ppm;L-VALINE (13C5, 99%);L-Valine Vetec(TM) reagent grade, >=98%;(s)-2-amino-3-methylbutanoicacid;(S)-2-Amino-3-methylbutansαure;(s)-2-amino-3-methylbutyricacid;(s)-alpha-amino-beta-methylbutyricacid
CAS: 72-18-4
MF: C5H11NO2
MW: 117.15
EINECS: 200-773-6
Product Categories: amino;alpha-Amino Acids;Amino Acid Derivatives;Biochemistry;Nutritional Supplements;Amino Acids;Amino Acids;Valine [Val, V];Amino Acids and Derivatives
Mol File: 72-18-4.mol
L-Valine Structure
 
L-Valine Chemical Properties
Melting point 295-300 °C (subl.)(lit.)
alpha 28 º (c=8, 6N HCl)
Boiling point 213.6±23.0 °C(Predicted)
density 1.23
refractive index 28 ° (C=8, HCl)
storage temp. Store at RT.
solubility H2O: 25 mg/mL
pka 2.29(at 25℃)
form powder
color White
PH 5.5-6.5 (100g/l, H2O, 20℃)
optical activity [α]20/D +27.0±0.5°, c = 5% in 5 M HCl
Water Solubility 85 g/L (20 ºC)
λmax λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.1
Merck 14,9909
BRN 1721136
InChIKey KZSNJWFQEVHDMF-BYPYZUCNSA-N
CAS DataBase Reference 72-18-4(CAS DataBase Reference)
NIST Chemistry Reference Valine(72-18-4)
EPA Substance Registry System L-Valine (72-18-4)
 
Safety Information
Hazard Codes Xn
Risk Statements 40
Safety Statements 24/25-36-22
WGK Germany 3
RTECS YV9361000
TSCA Yes
HS Code 29224995
Toxicity LD50 intraperitoneal in rat: 5390mg/kg
MSDS Information
Provider Language
2-Aminoisovaleric acid English
SigmaAldrich English
ACROS English
ALFA English
 
L-Valine Usage And Synthesis
Amino acids L-Valine is a kind of branched-chain amino acids (BCAA). Animal cannot synthesize it by itself. It must be obtained from the diet to meet their nutritional needs. Therefore L-valine belongs to the essential amino acids.
Amino acids are the basic structural unit of protein synthesis, and the predecessor of other amines that metabolism needs. They are indispensable materials in our life. At present, it is known that there are 20 to 30 amino acids. Some of them can be synthesized in the human body, which are known as non-essential amino acids. And some, called essential amino acids, cannot be synthesized in the human body that should be supplemented from the outside. Mammal cells need twelve essential amino acids: L-arginine, L-cystine, L-histidine, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L-valine. These amino acids are all laevoisomer, and some non-essential amino acids of dextroisomer may have inhibitory effect on cultured cells.
L-amino acids can easier to be absorbed than D-amino acids. And the absorption of D, L-methionine has no difference. There is competition between the body transport of amino acids. The transporting of an amino acid can be suppressed by the presence of another amino acid. For example, L-valine and L-methionine can inhibit the absorption of L-leucine. Excessive lysine in dietary can inhibit the absorption of arginine. High concentration (100mM) of L-valine has no effect on the absorption of L-methionine. Because it can be transported through another route.
Content Analysis About 200mg sample is accurately weighed, dissolved in 3ml formic acid and 50ml glacial acetic acid. Add 2 drops of crystal violet test solution (TS-74), then use 0.1mol/L perchloric acid to titrate the solution to green or blue disappear entirely. Each Ml0.1mol/L perchloric acid is equivalent to 11.72mg L-valine (C5H11NO2).
Chemical property White crystal or crystalline powder, odorless, bitter taste. Soluble in water, solubility in water of 8.85% at 25℃. Almost insoluble in ethanol, r, . melting point(decomposition point) 315℃, isoelectric point 5.96, [α]25D+28.3 (C = 1-2g/ml, in 5mol/L HCl).
Uses
  • Amino acids drugs, nutritional supplements. It can be used as the main component of aminophenol transfusion and synthesize aminophenol. L-Valine is one of the three branched-chain amino acids. It is essential amino acid. It can be used to treat liver failure and central nervous system dysfunction.
  • L-Valine is essential amino acid. The requirement for men is 10mg/(kg·d). Physiological effects of the L-form is 2 times of the D-type. L-Valine deficiency can cause neurological disorders, blastocolysis, loss of weight, anemia and the like. As nutritional supplements, it can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion. Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine is the essential amino acid. It can be used as one of pharmaceutical composition of amino acid infusion to synthesize drugs. It also can be used as food additives.
  • Nutritional supplements. It can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion.Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine can be used for biochemical research, the preparation of tissue culture media. It also used as amino acids nutritional drugs in medicine.
Description Valine (abbreviated as Val or V) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. L-Valine is one of 20 proteinogenic amino acids. Its codons are GUU, GUC, GUA, and GUG. This essential amino acid is classified as nonpolar. Human dietary sources are any proteinaceous foods such as meats, dairy products, soy products, beans and legumes.
Along with leucine and isoleucine, valine is a branched-chain amino acid. It is named after the plant valerian. In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. Because valine is hydrophobic, the hemoglobin is prone to abnormal aggregation.
Chemical Properties White or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol.
Uses L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grai ns, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.
Uses valine is an amino acid used as a skin-conditioning and odor-masking agent. It is more commonly used in hair care preparations than in skin care.
Definition ChEBI: The L-enantiomer of valine.
Biosynthesis Valine is an essential amino acid, hence it must be ingested, usually as a component of proteins. It is synthesized in plants via several steps starting from pyruvic acid. The initial part of the pathway also leads to leucine. The intermediate α-ketoisovalerate undergoes reductive amination with glutamate. Enzymes involved in this biosynthesis include :
Acetolactate synthase
Acetohydroxy acid isomeroreductase
Dihydroxyacid dehydratase
Valine aminotransferase.
Synthesis Reference(s) Tetrahedron Letters, 22, p. 2411, 1981 DOI: 10.1016/S0040-4039(01)82922-1
Chemical and Pharmaceutical Bulletin, 23, p. 167, 1975 DOI: 10.1248/cpb.23.167
Safety Profile Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Chemical Synthesis Racemic valine can be synthesized by bromination of isovaleric acid followed by amination of the α-bromo derivative
HO2CCH2CH(CH3)2 + Br2 → HO2CCHBrCH(CH3)2 + HBr
HO2CCHBrCH(CH3)2 + 2 NH3 → HO2CCH(NH2)CH(CH3)2 + NH4Br
.
Purification Methods Crystallise L-valine from water by addition of EtOH. It sublimes at 178-188o/0.03mm with 99.3% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Perrin J Chm Soc 3125 1958, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2368-23771961, Beilstein 4 IV 2659.]
Nomenclature According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons.