China Largest Factory Manufacturer L-Proline CAS 147-85-3 For stock delivery

Name: China Largest Factory Manufacturer L-Proline CAS 147-85-3 For stock delivery
Brand: Leader
SKU: LD
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L-Proline Basic information

Product Name:	L-Proline
Synonyms:	L-Proline ,L-2-Pyrrolidinecarboxylic acid;L-PROLINE, NATURAL;L-PROLINE, SYNTHETIC;L-(-)-PROLINE ((S)-(-)-PROLINE);L-PROLINE (13C5, 99%);L-PROLINE (13C5, 99%;L-PROLINE (D7, 97-98%);L(-)-Proline 0
CAS:	147-85-3
MF:	C5H9NO2
MW:	115.13
EINECS:	205-702-2
Product Categories:	amino;Amino Acids;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Food & Feed ADDITIVES;Amino Acid Derivatives;Proline [Pro, P];Amino Acids;Amino Acids and Derivatives
Mol File:	147-85-3.mol

L-Proline Chemical Properties

Melting point	228 °C (dec.)(lit.)
alpha	-85.5 º (c=4, H2O)
Boiling point	215.41°C (rough estimate)
density	1.35
FEMA	3319 \| L-PROLINE
refractive index	-85 ° (C=4, H2O)
storage temp.	Store at RT.
solubility	H₂O: 50 mg/mL
pka	1.95, 10.64(at 25℃)
form	powder
color	White
PH	6.0-7.0 (25℃, 1M in H2O)
optical activity	[α]20/D 85.0±1.0°, c = 5% in H2O
Water Solubility	soluble
λmax	λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.05
Sensitive	Hygroscopic
JECFA Number	1425
Merck	14,7780
BRN	80810
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	ONIBWKKTOPOVIA-UHFFFAOYSA-N
CAS DataBase Reference	147-85-3(CAS DataBase Reference)
NIST Chemistry Reference	Proline(147-85-3)
EPA Substance Registry System	L-Proline (147-85-3)

Safety Information

MSDS Information

Provider	Language
2-Pyrrolidinecarboxylic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

L-Proline Usage And Synthesis

Chemical Properties	White crystalline powder
Chemical Properties	L-Proline, an amino acid, is odorless or has a slight, characteristic odor with a slightly sweet taste.
Occurrence	Reported found as a component in many proteins; also widely occurring as the free acid in natural products. A major constituent of collagen, the main fibrous protein found in bone, cartilage and other connective tissue.
Uses	amino acid, nutrient
Uses	L-Proline is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.
Preparation	From α-piperidone; from cyclopentantone; from l-glutamic acid.
Purification Methods	A likely impurity is hydroxyproline. Purify L-proline via its picrate which is crystallised twice from water, then decomposed with 40% H2SO4. The picric acid is extracted with diethyl r, the H2SO4 in solution is precipitated with Ba(OH)2, and the filtrate is evaporated. The residue is crystallised from hot absolute EtOH [Mellan & Hoover J Am Chem Soc 73 3879 1951] or EtOH/Et2O. Its solubility in H2O is >100%. It sublimes at 182-187o/0.3mm with 99.4% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. It is hygroscopic and is stored in a desiccator. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2178-2199 1961, Beilstein 22 III/IV 8, 22/1 V 31.]

L-Proline Preparation Products And Raw materials

Raw materials	Tri-->Ammonium chloride-->Isopropyl alcohol-->Aluminum oxide-->D(+)-Glucose-->Triethanolamine-->Potassium borohydride-->L-Glutamic acid-->Casein-->Gelatin-->PICRIC ACID
Preparation Products	2-(2-Aminoethyl)-1-methylpyrrolidine-->Enalapril-->Captopril-->Levosulpiride-->(S)-2-Methylproline-->(S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole-->2-Fluoro-4-(methylsulfonyl)aniline-->(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol-->D-Proline-->Lisinopril-->D-(S)-3-acetylthio-2-methylpropionylL-proline-->R(-)-DENOPAMINE-->DL-Proline-->Methyl L-prolinate hydrochloride

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