| L-Citrulline Basic information |
| Product Name: | L-Citrulline |
| Synonyms: | Ibuprofen Impurity 78;Arginine Impurity 2(Arginine EP Impurity B)(Citrulline);L-CTRULLINE;L-Citrullne;Arginine EP Impurity B;n5-(aminocarbonyl)-l-ornithin;N5-(aminocarbonyl)-L-Ornithine;ALPHA-AMINO-DELTA-UREIDO-N-VALERIC ACID |
| CAS: | 372-75-8 |
| MF: | C6H13N3O3 |
| MW: | 175.19 |
| EINECS: | 206-759-6 |
| Product Categories: | Amino Acids;Citruline [Cit];Amino Acids;Unusual Amino Acids;Biochemistry;non-Proteinorganic Amino Acids;Nutritional Supplements;L-Amino Acids;Aliphatics;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 372-75-8.mol |
| L-Citrulline Chemical Properties |
| Melting point | 214 °C |
| alpha | 25.5 º (c=8, 6N HCl) |
| Boiling point | 306.48°C (rough estimate) |
| density | 1.2919 (rough estimate) |
| refractive index | 26 ° (C=8, 6mol/L HCl) |
| storage temp. | Store at 0-5°C |
| pka | 2.43(at 25℃) |
| form | Crystals or Crystalline Powder |
| color | White |
| Odor | Odorless |
| Water Solubility | 200 g/L (20 ºC) |
| Merck | 14,2331 |
| BRN | 6055157 |
| InChIKey | RHGKLRLOHDJJDR-BYPYZUCNSA-N |
| CAS DataBase Reference | 372-75-8(CAS DataBase Reference) |
| EPA Substance Registry System | L-Ornithine, N5-(aminocarbonyl)- (372-75-8) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29241900 |
| MSDS Information |
| Provider | Language |
|---|---|
| L(+)-2-Amino-5-ureidovaleric acid | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| L-Citrulline Usage And Synthesis |
| Chemical Properties | White powder |
| Originator | StaminO2,ErgoPharm |
| Uses | An amino acid, L-Citrulline can be used in the treatment of asthenia and as an essential intermediate in the biosynthesis of nitric oxide. |
| Uses | An essential intermediate in the biosynthesis of nitric oxide. |
| Manufacturing Process | Citrulline is obtained as a result of a reaction of L-arginine hydrochloride with sodium hydroxide, copper oxide and hydrogen sulfide. In practice it is usually used as malate salt |
| Therapeutic Function | Stimulant, Detoxicant |
| Purification Methods | Likely impurities are arginine and ornithine. Crystallise S-citrulline from water by adding 5 volumes of EtOH. Also crystallise it from water by addition of MeOH. [Ellenbogen J Am Chem Soc 74 5198 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2491-2494 1961, Beilstein 4 IV 2647.] |
| L-Citrulline Preparation Products And Raw materials |
| Raw materials | Hydroxide |