China Largest Factory Manufacturer CAPE / Caffeic acid phenethyl ester CAS 104594-70-9 For stock delivery
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Purity99.9%
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UseHealth Care
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OriginChina
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Package1KG/Tin 25KG/Drum*Carton
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ManufacturerXI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
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Place of OriginCHINA
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Brand NameLeader
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CertificationISO,GMP,SGS,HALA,KOSER,HACCP
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Model NumberLD
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Minimum Order Quantity25KGS
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PriceNegotiate Depend on order quantity
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Packaging Details25KG/Drum
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Delivery Time2-3 working days
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Payment TermsWestern Union, MoneyGram, T/T, L/C
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Supply Ability10MTS/Month
China Largest Factory Manufacturer CAPE / Caffeic acid phenethyl ester CAS 104594-70-9 For stock delivery
| Phenethyl caffeate Basic information |
| Product Name: | Phenethyl caffeate |
| Synonyms: | Caffeic Acid 2-Phenylethyl Ester;CAFFEIC ACID PHENETHYLESTER (CAPE);CAPE,PhenethylCaffeate;CAFFEIC ACID PHENETHYL ESTER(CAPE)(P);KAFFEESUREPHENYLETHYLESTER;CAFFEICACIDPHENYLETHERESTER;3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester;Cafestol Acid Phenethyl Ester |
| CAS: | 104594-70-9 |
| MF: | C17H16O4 |
| MW: | 284.31 |
| EINECS: | 627-151-0 |
| Product Categories: | HIV/AIDS/Related Products;Apoptosis Inducers;Miscellaneous Natural Products;Inhibitors;Tyrosine Kinase Inhibitors;Cytokine signaling |
| Mol File: | 104594-70-9.mol |
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| Phenethyl caffeate Chemical Properties |
| Melting point | 127-129℃ |
| Boiling point | 498.6±45.0 °C(Predicted) |
| density | 1.266±0.06 g/cm3(Predicted) |
| storage temp. | Store at 0°C |
| solubility | Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol. |
| pka | 8.46±0.20(Predicted) |
| form | White to off-white solid |
| color | off-white |
| Sensitive | Light Sensitive |
| λmax | 323nm(lit.) |
| InChIKey | SWUARLUWKZWEBQ-VQHVLOKHSA-N |
| CAS DataBase Reference | 104594-70-9(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-38-37-36 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | UD3334375 |
| HS Code | 29182900 |
| Phenethyl caffeate Usage And Synthesis |
| Description | Phenylethyl caffeate is one of the allergens of propolis (bee glue); also contained in poplar-bud secretions. |
| Chemical Properties | Off-White Solid |
| Uses | antineoplastic, antiinflammatory, immunomodulator, NFkB blocker |
| Uses | Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. |
| Biological Activity | Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF- κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. |
| Contact allergens | Capee is one of the allergens of propolis (bee glue). It is also contained in poplar bud secretions. |
| Anticancer Research | Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017). |
| Phenethyl caffeate Preparation Products And Raw materials |
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