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China Northwest Factory Manufacturer Polydatin CAS 65914-17-2 For stock delivery

China Northwest Factory Manufacturer Polydatin CAS 65914-17-2 For stock delivery

  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Northwest Factory Manufacturer Polydatin CAS 65914-17-2 For stock delivery

Polydatin Basic information
Product Name: Polydatin
Synonyms: 3,4',5-TRIHYDROXYSTILBENE-3-BETA-MONOGLUCOSIDE;3,4'-5-TRIHYDROXYSTILBENE-3-BETA-D-GLUCOPYRANOSIDE;TRANS-RESVERATROL 3-O-BETA-D-GLUCURONIDE;TRANS-RESVERATROL-O-BETA-GLUCOSIDE;3,4'-5-TRIHYDROXYSTILBEENE-3-BETA-D-GLU&;Polydatine;3,4'-5-trihydroxystilbene-3-β-d-glucopyranoside;3,4',5-Trihydroxystilbene-3-b-D-glucopyranoside
CAS: 65914-17-2
MF: C20H22O8
MW: 390.38
EINECS:  
Product Categories: Inhibitors;natural product;Natural Plant Extract;Improve Organism Immunity;plant extract;Herb extract;Carbohydrate Synthesis;Monosaccharides;Specialty Synthesis
Mol File: 65914-17-2.mol
Polydatin Structure
 
Polydatin Chemical Properties
Melting point 223-226 °C(lit.)
alpha -55 º (c=1,)
Boiling point 707.7±60.0 °C(Predicted)
density 1.521±0.06 g/cm3(Predicted)
form White to off-white solid.
pka 9.31±0.10(Predicted)
color White to off-white solid.
optical activity [α]20/D 55°, c = 1 in
BRN 54837
CAS DataBase Reference 65914-17-2(CAS DataBase Reference)
 
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29389090
MSDS Information
Provider Language
SigmaAldrich English
 
Polydatin Usage And Synthesis
Description Polydatin (PD) is a major chemical component of Polygonum cuspidatum and it could also be found in a variety of other sources. PD is a polyphenol belonging to the chemical family of stilbenoids. Previous studies have shown that PD exhibits many pharmacological activities, including cardioprotective, neuroprotective, and antioxidative activities. With vascular dementia (VaD) rat models, PD markedly attenuated cognitive deficits. Biochemical analysis revealed that PD decreased the production of malondialdehyde (MDA) and significantly increased superoxide dismutase and catalase activities. Additionally, PD effectively alleviated the injuries of cultured neurons induced by oxygen–glucose deprivation. The therapeutic potential of PD for VaD seems related to its antioxidative activity and the direct protection of neurons. Furthermore, PD could also effectively inhibit the polymerization of amyloid-β peptides, which is a major mark in the progression of pathogenesis in Alzheimer’s disease (AD). These results suggest that PD is a promising drug candidate or nutraceutical for the treatment of VaD and AD.
Uses Polydatin, a type of polyphenolic phytoalexin, has many physiological and pharmacological effects including anti-inflammatory and anti-oxidative activities. Polydatin is an effective candidate drug for the protection of photo-inflammation. Polydatin exhibits therapeutic potential for vascular dementia, most likely due to its anti-oxidant activity and the direct protection of neurons.
Uses Trans-piceid is a stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. It has a role as a metabolite, a potassium channel modulator, an anti-arrhythmia drug, a hepatoprotective agent, an antioxidant and a nephroprotective agent. It is a stilbenoid, a polyphenol, a beta-D-glucoside and a monosaccharide derivative. It derives from a trans-resveratrol.
Biological Functions Stilbene found in medicinal herbs. Antioxidant, anti-inflammatory and neuroprotective.
Biological Activity Polydatin is a natural stilbene originally isolated from the rhizome of P. cuspidatum, which is used in traditional Chinese medicine for analgesic, antipyretic, and diuretic effects.Like other stilbenes, this resveratrol glucoside has antioxidant activity.Polydatin has diverse effects in cells, tissues, and animals, including reducing cytotoxicity, inflammation, and atherosclerosis.
Clinical Use Polydatin (PD, also named pieceid, (E)-piceid, (E)-polydatin, trans-polydatin, 3,40 ,5-trihydroxystilbene-3-b-D-glucoside) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), a traditional Chinese medicine that has long been used in China as an analgesic, anti-pyretic, diuretic and expectorant. It is a glucoside of resveratrol (3,40 ,5-trihydroxystilbene) in which the glucoside group bound to the position C-3 substitutes a hydroxyl group, belonging to stilbene phytoalexins. Polydatin can also be detected in grape, peanut, hop cones, red wines, hop pellets, a-containing products, chocolate products and many daily diets. Polydatin is the most abundant form of resveratrol in nature. Polydatin shows many pharmacological effects confirmed by numerous investigations, including cardiovascular protection, neuroprotection, anti-inflammation, immunoregulation, anti-oxidation, anti-tumour and liver and lung protective effects. Polydatin has found its way into clinical trials for the treatment of hemorrhagic shock and irritable bowel syndrome.
 
Polydatin Preparation Products And Raw materials