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China Northwest Factory Manufacturer Polydatin CAS 65914-17-2 For stock delivery

Name: China Northwest Factory Manufacturer Polydatin CAS 65914-17-2 For stock delivery
Brand: Leader
SKU: LD
Rating: 4.8 (121 reviews)

Brand Name:	Leader
Model Number:	LD
MOQ:	25KGS
Price:	Negotiate Depend on order quantity
Payment Terms:	Western Union, MoneyGram, T/T, L/C
Supply Ability:	10MTS/Month

Detail Information

Product Description

Detail Information

Place of Origin:

CHINA

Certification:

ISO,GMP,SGS,HALA,KOSER,HACCP

Purity:

99.9%

Use:

Health Care

Origin:

China

Package:

1KG/Tin 25KG/Drum*Carton

Manufacturer:

XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD

Packaging Details:

25KG/Drum

Supply Ability:

10MTS/Month

Product Description

Polydatin Basic information

Product Name:	Polydatin
Synonyms:	3,4',5-TRIHYDROXYSTILBENE-3-BETA-MONOGLUCOSIDE;3,4'-5-TRIHYDROXYSTILBENE-3-BETA-D-GLUCOPYRANOSIDE;TRANS-RESVERATROL 3-O-BETA-D-GLUCURONIDE;TRANS-RESVERATROL-O-BETA-GLUCOSIDE;3,4'-5-TRIHYDROXYSTILBEENE-3-BETA-D-GLU&;Polydatine;3,4'-5-trihydroxystilbene-3-β-d-glucopyranoside;3,4',5-Trihydroxystilbene-3-b-D-glucopyranoside
CAS:	65914-17-2
MF:	C20H22O8
MW:	390.38
EINECS:
Product Categories:	Inhibitors;natural product;Natural Plant Extract;Improve Organism Immunity;plant extract;Herb extract;Carbohydrate Synthesis;Monosaccharides;Specialty Synthesis
Mol File:	65914-17-2.mol

Polydatin Chemical Properties

Melting point	223-226 °C(lit.)
alpha	-55 º (c=1,)
Boiling point	707.7±60.0 °C(Predicted)
density	1.521±0.06 g/cm3(Predicted)
form	White to off-white solid.
pka	9.31±0.10(Predicted)
color	White to off-white solid.
optical activity	[α]20/D 55°, c = 1 in
BRN	54837
CAS DataBase Reference	65914-17-2(CAS DataBase Reference)

Safety Information

Safety Statements	22-24/25
WGK Germany	3
HS Code	29389090

MSDS Information

Provider	Language
SigmaAldrich	English

Polydatin Usage And Synthesis

Description	Polydatin (PD) is a major chemical component of Polygonum cuspidatum and it could also be found in a variety of other sources. PD is a polyphenol belonging to the chemical family of stilbenoids. Previous studies have shown that PD exhibits many pharmacological activities, including cardioprotective, neuroprotective, and antioxidative activities. With vascular dementia (VaD) rat models, PD markedly attenuated cognitive deficits. Biochemical analysis revealed that PD decreased the production of malondialdehyde (MDA) and significantly increased superoxide dismutase and catalase activities. Additionally, PD effectively alleviated the injuries of cultured neurons induced by oxygen–glucose deprivation. The therapeutic potential of PD for VaD seems related to its antioxidative activity and the direct protection of neurons. Furthermore, PD could also effectively inhibit the polymerization of amyloid-β peptides, which is a major mark in the progression of pathogenesis in Alzheimer’s disease (AD). These results suggest that PD is a promising drug candidate or nutraceutical for the treatment of VaD and AD.
Uses	Polydatin, a type of polyphenolic phytoalexin, has many physiological and pharmacological effects including anti-inflammatory and anti-oxidative activities. Polydatin is an effective candidate drug for the protection of photo-inflammation. Polydatin exhibits therapeutic potential for vascular dementia, most likely due to its anti-oxidant activity and the direct protection of neurons.
Uses	Trans-piceid is a stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. It has a role as a metabolite, a potassium channel modulator, an anti-arrhythmia drug, a hepatoprotective agent, an antioxidant and a nephroprotective agent. It is a stilbenoid, a polyphenol, a beta-D-glucoside and a monosaccharide derivative. It derives from a trans-resveratrol.
Biological Functions	Stilbene found in medicinal herbs. Antioxidant, anti-inflammatory and neuroprotective.
Biological Activity	Polydatin is a natural stilbene originally isolated from the rhizome of P. cuspidatum, which is used in traditional Chinese medicine for analgesic, antipyretic, and diuretic effects.Like other stilbenes, this resveratrol glucoside has antioxidant activity.Polydatin has diverse effects in cells, tissues, and animals, including reducing cytotoxicity, inflammation, and atherosclerosis.
Clinical Use	Polydatin (PD, also named pieceid, (E)-piceid, (E)-polydatin, trans-polydatin, 3,40 ,5-trihydroxystilbene-3-b-D-glucoside) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), a traditional Chinese medicine that has long been used in China as an analgesic, anti-pyretic, diuretic and expectorant. It is a glucoside of resveratrol (3,40 ,5-trihydroxystilbene) in which the glucoside group bound to the position C-3 substitutes a hydroxyl group, belonging to stilbene phytoalexins. Polydatin can also be detected in grape, peanut, hop cones, red wines, hop pellets, a-containing products, chocolate products and many daily diets. Polydatin is the most abundant form of resveratrol in nature. Polydatin shows many pharmacological effects confirmed by numerous investigations, including cardiovascular protection, neuroprotection, anti-inflammation, immunoregulation, anti-oxidation, anti-tumour and liver and lung protective effects. Polydatin has found its way into clinical trials for the treatment of hemorrhagic shock and irritable bowel syndrome.

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China Northwest Factory Manufacturer Polydatin CAS 65914-17-2 For stock delivery

China Northwest Factory Manufacturer Polydatin CAS 65914-17-2 For stock delivery