2-Hydroxy-4-benzophenone-5-sulfonic acid Basic information |
Product Name: | 2-Hydroxy-4-benzophenone-5-sulfonic acid |
Synonyms: | Uvistat 1121;UV ABSORBER HMBS;5-BENZOYL-4-HYDROXY-2-BENZENESULFONIC ACID;TIMTEC-BB SBB002961;SULISOBENZONE;spectra-sorb uv 284;2-HYDROXY-4-BENZOPHENONE-5-SULPHONIC ACID;Uv absorber BP-4(UV-284) |
CAS: | 4065-45-6 |
MF: | C14H12O6S |
MW: | 308.31 |
EINECS: | 223-772-2 |
Product Categories: | Organic acids;Industrial/Fine Chemicals;Aromatic Benzophenones & Derivatives (substituted);Building Blocks;Chemical Synthesis;SUNGARD;Organic Building Blocks;Sulfonic/Sulfinic Acids;Sulfur Compounds |
Mol File: | 4065-45-6.mol |
2-Hydroxy-4-benzophenone-5-sulfonic acid Chemical Properties |
Melting point | 170 °C |
Boiling point | 0°C |
density | 1.4574 (rough estimate) |
refractive index | 1.5300 (estimate) |
Fp | 0°C |
storage temp. | -20°C |
form | neat |
pka | -0.70±0.50(Predicted) |
Merck | 14,8983 |
BRN | 2889165 |
InChIKey | CXVGEDCSTKKODG-UHFFFAOYSA-N |
CAS DataBase Reference | 4065-45-6(CAS DataBase Reference) |
EPA Substance Registry System | Sulisobenzone (4065-45-6) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36-37/39-36/37/39-27 |
WGK Germany | 1 |
RTECS | DB5044300 |
TSCA | Yes |
HS Code | 29147000 |
Hazardous Substances Data | 4065-45-6(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
ACROS | English |
ALFA | English |
2-Hydroxy-4-benzophenone-5-sulfonic acid Usage And Synthesis |
Chemical Properties | white to yellowish powder |
Originator | Uval,Dome,US,1965 |
Uses | 2-Hydroxy-4-benzophenone-5-sulfonic acid is a commonly used, FDA approved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure. |
Uses | sulisobenzone is the drug name for benzophenone-4, a sunscreen chemical. |
Uses | ultraviolet screen |
Uses | Ultraviolet absorber for leather and textile fibers; in cosmetics and shampoos. |
Manufacturing Process | 663 g of dichloroethane and 74.6 g 2-hydroxy-4-benzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux condenser and dropping funnel and a heating mantle. The solution was heated to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off 66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic acid was added slowly over a period of about two hours. The rate of addition was regulated by the speed of evolution of the HCl. After all the chlorosulfonic acid was added, the charge was still maintained at reflux for an additional 15 minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of product were obtained. |
Brand name | Sungard (Bayer). |
Therapeutic Function | Sunscreen agent |
Contact allergens | BZP-4 is widely used in cosmetics, particularly shampoos and hair products. Cross-reactivity is rarely expected in patients photoallergic to ketoprofen. |
2-Hydroxy-4-benzophenone-5-sulfonic acid Preparation Products And Raw materials |
Raw materials | Resorcinol-->Dibenzene-->Oxybenzone-->Chlorosulfonic acid |