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China Northwest Factory Manufacturer Trometamol / Tris Base CAS 77-86-1 For stock delivery

China Northwest Factory Manufacturer Trometamol / Tris Base CAS 77-86-1 For stock delivery

Products - Cosmetics Ingredients
  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Northwest Factory Manufacturer Trometamol / Tris Base CAS 77-86-1 For stock delivery

  • China Northwest Factory Manufacturer Trometamol / Tris Base CAS 77-86-1 For stock delivery
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Tris Base Basic information
Chemical Properties Uses of Biology Uses
Product Name: Tris Base
Synonyms: OmniPur TRIS -CAS 77-86-1 - Calbiochem;Tris Base, Molecular Biology Grade - CAS 77-86-1 - Calbiochem;Tris Base, ULTROL Grade - CAS 77-86-1 - Calbiochem;Tris Buffer, 1.0 M, pH 8.0, Molecular Biology Grade - CAS 77-86-1 - Calbiochem;Tris Buffer, 100 mM, pH 7.4, Molecular Biology Grade - CAS 77-86-1 - Calbiochem;Tris(Hydroxymethyl)aminomethane (Trometamol) high purity;1-[ethyl(hydroxymethyl)amino]ethane-1,2-diol;TRIS,Tromethamine, Trometamol
CAS: 77-86-1
MF: C4H11NO3
MW: 121.14
EINECS: 201-064-4
Product Categories: tris;Pharmaceutical intermediates;ACS Grade Buffers;Amino Alcohols;Biological Buffers;API;Biochemistry;Reagents for Electrophoresis;Buffer;Buffers A to Z;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
Mol File: 77-86-1.mol
Tris Base Structure
 
Tris Base Chemical Properties
Melting point 167-172 °C(lit.)
Boiling point 219-220 °C10 mm Hg(lit.)
density 1,353 g/cm3
vapor pressure 0.0267 hPa (20 °C)
refractive index 1.4170 (estimate)
Fp 219-220°C/10mm
storage temp. 2-8°C
solubility H2O: 4 M at 20 °C, clear, colorless
form crystalline
color white
PH 10.5-12.0(4 m in water, 25 °C)
PH Range 7 - 9
pka 8.1(at 25℃)
Water Solubility 550 g/L (25 ºC)
λmax λ: 260 nm Amax: 0.10
λ: 280 nm Amax: 0.08
Sensitive Hygroscopic
Merck 14,9772
BRN 741883
Stability: Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
InChIKey LENZDBCJOHFCAS-UHFFFAOYSA-N
CAS DataBase Reference 77-86-1(CAS DataBase Reference)
NIST Chemistry Reference 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
EPA Substance Registry System Tris(hydroxymethyl)aminomethane (77-86-1)
 
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39-24/25-23
WGK Germany 2
RTECS TY2900000
F 3
TSCA Yes
HazardClass IRRITANT
HS Code 29221980
Hazardous Substances Data 77-86-1(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rat > 5000 mg/kg
MSDS Information
Provider Language
2-Amino-2-(hydroxymethyl)-1,3-propanediol English
SigmaAldrich English
ACROS English
ALFA English
 
Tris Base Usage And Synthesis
Chemical Properties White crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in r, carbon tetrachloride,copper,aluminum corrosion effects,irritant.
Uses of Biology Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.
Uses 1, Tris buffer, only nucleic acids and proteins are widely used as solvents.
2, Tris is used for protein crystal growth under different pH conditions.
3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers.
4, Tris is a major component of protein electrophoresis buffer.
5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates.
6, Tris titrated also used as standard.
Chemical Properties White, crystalline solid. PH (0.1M aqueous solution) 10.6, corrosive to copper, brass, aluminum. Solubility in water 80 g/100 cc (20C). Combustible.
Originator Trisaminol,Bellon,France,1964
Uses tromethamine can help mask odor in a formulation. It is also used as a buffer, keeping product pH stable.
Uses In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning Compounds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.
Manufacturing Process Nitromethane is reacted with formaldehyde to give tris(hydroxymethyl)nitromethane in an initial step. This intermediate may be reduced by catalytic hydrogenation (US Patent 2,174,242) or by electrolytic reduction (US Patent 2,485,982).
Brand name Tham (Hospira).
Therapeutic Function Antacid
Biological Activity Commonly used laboratory reagent
Purification Methods TRIS can ordinarily be obtained in highly pure form suitable for use as an acidimetric standard. If only impure material is available, it should be crystallised from 20% EtOH, aqueous MeOH (m 171.1o) or isopropanol (m 172-173o). Dry it in a vacuum desiccator over P2O5 or CaCl2. Alternatively, it is dissolved in twice its weight of water at 55-60o, filtered, concentrated to half its volume and poured slowly, with stirring, into about twice its volume of EtOH. The crystals which separate on cooling to 3-4o are filtered off, washed with a little MeOH, air dried by suction, then finally ground and dried in a vacuum desiccator over P2O5. It has also been recrystallised from water, MeOH or aqueous MeOH, and vacuum dried at 80o for 2 days. [Beilstein 4 H 303, 4 III 857, 4 IV 1903.]
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