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China Northwest Factory Manufacturer D-(+)Trehalose Dihydrate Cas 6138-23-4 For stock delivery

China Northwest Factory Manufacturer D-(+)Trehalose Dihydrate Cas 6138-23-4 For stock delivery

Products - Cosmetics Ingredients
  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Northwest Factory Manufacturer D-(+)Trehalose Dihydrate Cas 6138-23-4 For stock delivery

  • China Northwest Factory Manufacturer D-(+)Trehalose Dihydrate Cas 6138-23-4 For stock delivery
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D(+)-Trehalose dihydrate Basic information
Product Name: D(+)-Trehalose dihydrate
Synonyms: D-ALPHA,ALPHA-TREHALOSE DIHYDRATE;D(+)-TREHALOSE;D-TREHALOSE;D-(+)-TREHALOSE DIHYDRATE;D-TREHALOSE DIHYDRATE;D(+)TREHALOSE DIHYDRATE CELL*CULTURE TES TED;D(+)-TREHALOSE DIHYDRATE, FOR MICRO-BIOL OGY;.alpha.-D-Glucopyranoside, .alpha.-D-glucopyranosyl, dihydrate
CAS: 6138-23-4
MF: C12H22O11·2H2O
MW: 378.33
EINECS: 612-140-5
Product Categories: Basic Sugars (Mono & Oligosaccharides);Biochemistry;Sugars, Carbohydrates & Glucosides;Disaccharides;Sugars;Dextrins,Sugar & Carbohydrates
Mol File: 6138-23-4.mol
D(+)-Trehalose dihydrate Structure
 
D(+)-Trehalose dihydrate Chemical Properties
Melting point 97-99 °C(lit.)
alpha 179 º (c=2, H2O)
Boiling point 115.3 °C
FEMA 4600 | TREHALOSE, DIHYDRATE
refractive index 181 ° (C=7, H2O)
storage temp. Store at RT.
solubility H2O: 50 mg/mL
form powder
optical activity [α]20/D +179±3°, c = 2% in H2O
Water Solubility 68.9 g/100 mL (20 ºC)
Sensitive Hygroscopic
Merck 14,9580
BRN 5322018
InChIKey DPVHGFAJLZWDOC-NYAOJISMSA-N
CAS DataBase Reference 6138-23-4(CAS DataBase Reference)
 
Safety Information
Hazard Codes Xi
Risk Statements 38-36/37/38
Safety Statements 37/39-26-24/25
WGK Germany 2
RTECS LZ5776547
F 3-10
TSCA Yes
HS Code 29400000
MSDS Information
Provider Language
ACROS English
SigmaAldrich English
ALFA English
 
D(+)-Trehalose dihydrate Usage And Synthesis
Chemical Properties white to off-white crystalline powder
Chemical Properties Trehalose occurs as virtually odorless, white or almost white crystals with a sweet taste (approximately 45% of the sweetness of sucrose).
Uses D-(+)-Trehalose is a disaccharide composed of two α-glucose units. D-(+)-Trehalose is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations. D-(+)-Trehalose is also used as a protein stabilize.
Uses Food additive; pharmaceutical excipient
Uses An osmolyte, chemical chaperone, and inducer of autophagy.
Uses Stabilizes cells during freezing, freeze-drying and air-drying. Sweetener and stabilizer in foods; cryoprotectant for freeze-dried foods. Additive in cosmetics and personal care products.
Production Methods Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.
Pharmaceutical Applications Trehalose is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.
Safety Trehalose is used in cosmetics, foods, and parenteral and nonparenteral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
In the gut, trehalose is rapidly metabolized to glucose by the specific enzyme trehalase. A small minority of the population exhibits a primary (hereditary) or secondary (acquired) trehalase deficiency and thus may experience intestinal discomfort after ingestion of excessive amounts of trehalose owing to the osmotic activity of undigested trehalose in the gut. However, smaller amounts of trehalose are tolerated by such individuals without any symptoms.
Trehalose is used as a sweetener and is reported to have substantially less cariogenic potential than sucrose.
LD50 (dog, IV): >1 g/kg
LD50 (dog, oral): >5 g/kg
LD50 (mouse, IV): >1 g/kg
LD50 (mouse, oral): >5 g/kg
LD50 (rat, IV): >1 g/kg
LD50 (rat, oral): >5 g/kg
storage Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
Trehalose should be stored in a cool, dry place in a well-sealed container.
Purification Methods α,α-D(+)-Trehalose crystallises (as the dihydrate) from aqueous EtOH. Dry it at 13o. For the anhydrous compound dissolve 10g in pyridine (200mL) and distil off this solvent at atmospheric pressure, and when the temperature rises to 115.3o all the H2O is removed and 73mL of distillate is collected. Most of the anhydrous material crystallises out at this stage. The crystals are collected (6.8g), washed with Et2O to give 6.1g of anhydrous product. Higher yields are obtained by slightly more prolonged distillation. [Birch J Chem Soc 3489 1965, X-ray cryst: Brown et al. Acta Cryst 28 3145 1972, Beilstein 17/8 V 3.]
Incompatibilities Trehalose is incompatible with strong oxidizing agents, especially in the presence of heat.
Regulatory Status GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.
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