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China Northwest Factory Manufacturer Betulin Cas 473-98-3 For stock delivery

China Northwest Factory Manufacturer Betulin Cas 473-98-3 For stock delivery

Products - Cosmetics Ingredients
  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Northwest Factory Manufacturer Betulin Cas 473-98-3 For stock delivery

  • China Northwest Factory Manufacturer Betulin Cas 473-98-3 For stock delivery
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Betulin Basic information
Extract Physical and Chemical Properties Extraction method Identification method Physiological functions Storage References
Product Name: Betulin
Synonyms: Lup-20(29)-ene-3,28-diol, (3β)-;Betuline;BETULIN(P);betula camphor;BETULIN hplc;Betulin,Betulinol,Betulol,Betulenol;3b,28-Dihydroxylup-20(29)-ene;Betulinic alcohol
CAS: 473-98-3
MF: C30H50O2
MW: 442.72
EINECS: 207-475-5
Product Categories: Triterpenoids;Tri-Terpenoids;Pentacyclic Triterpenes;chemical reagent;pharmaceutical intermediate;natural product;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File: 473-98-3.mol
Betulin Structure
 
Betulin Chemical Properties
Melting point 256-257 °C(lit.)
alpha D15 +20° (c = 2 in pyridine)
Boiling point 493.26°C (rough estimate)
density 0.9882 (rough estimate)
refractive index 1.5045 (estimate)
storage temp. 2-8°C
form Off-white powder
pka 15.10±0.10(Predicted)
Merck 14,1189
InChIKey FVWJYYTZTCVBKE-ROUWMTJPSA-N
CAS DataBase Reference 473-98-3(CAS DataBase Reference)
NIST Chemistry Reference Betulin(473-98-3)
 
Safety Information
Hazard Codes Xn,Xi
Risk Statements 36/37/38-20/21/22-68/20/21/22-68
Safety Statements 36/37-36-26
WGK Germany 3
RTECS OK5755000
HS Code 29181985
MSDS Information
Provider Language
Betulin English
SigmaAldrich English
 
Betulin Usage And Synthesis
Extract Betulin is an extract from bark of the white birch tree, which has been known since the 18th century and is chemically defined. Betulin was discovered by German-Russian chemist Johann Tobias Lowitz. He was the first scientist to study and characterise betulin, and in doing was one of the first to isolate an active plant ingredient.
Betulin is a substance of pure plant origin that gives the birch bark its typical white colour. Betulin protects birch trees from environmental effects, such as extreme temperatures, pest infestations and solar radiation.
Physical and Chemical Properties It is white crystalline powder, soluble in alcohol, chloroform and benzene, slightly soluble in cold water, petroleum r.
Extraction method Currently Betulin is obtained mainly through direct extraction, and mainly by solvent reflux extraction and recrystallization purification
Specifically:
1. Extract betulin from ethanol solution. After heating reflux about 5h, the extract is vacuum distillated and recrystallized with ethanol for 2 to 3 times with ethanol to obtain crude product of betulin.
2. The crude product was recrystallized from methanol/chloroform (1: 1) (every 80g crude product requires 300mL methanol/chloroform solution).The mixture is allowed to stand overnight and then suction filtered to obtain white needle-like betulin.
3. Ultrasonic treatment for 20min when refluxing is carried out, and the extraction yield and product purity of betulin can be improved through the destruction of bark organization.
4. The optimum conditions of supercritical CO2 fluid extraction are as follows: the amount of modifier was 115mL/(g birch bark powder); extraction pressure is 20MPa; extraction temperature was 55 ℃; liquid CO2 flow rate was 10kg/h.
Identification method HPLC conditions for betulin:
Isolated Constituent: Betulin(10μl sample injection)
Column Stationary Phase: C18(150×2)mm 5μ
Column Mobile phase: Acetonitrile/water =30:70
Flow rate (ml/min)；0.2Detection Wavelength (nm):270
Column Temperature:30℃
Physiological functions
  • Betulin and its derivatives as biological agents has shown great potential in the treatment of HIV and cancer by interfering with the post-life cycle of the virus, which is related to the entry as well as growth and maturing of virus.
  • As an effective anti-tumor drug, it can directly cause certain types of tumor cells to start self-destruction of the apoptosis program, and can slow down the growth of several types of tumor cells.
  • It can reduce dietary induced obesity, reduce lipid content in serum and tissue and improve insulin sensitivity.
  • It has mild anti-inflammatory properties at higher concentrations, and its anti-inflammatory properties are largely due to inhibition of non-neural gene pathways.
  • Betulin in the body can inhibit the maturation of sterol regulatory element binding protein (SBERPs), thereby reducing the biosynthesis of cholesterol and fatty acid.
  • In addition, with its anti-inflammatory, anti-virus effect and functions of inhibiting protein dissolution in the hair fiber, improving the luster of damaged hair and promoting hair growth and other activities, it can be used in food, cosmetics and pharmaceutical industries.
Storage Cool and dry, kept from light and temperature.
References http://www.imlan.de/en/infothek/what-is-betulin.html
Chemical Properties crystals
Uses antineoplastic, antihyperlipidemia
Uses birch bark extract is described as having anti-irritant and antiseptic properties, and effective in acne treatment. It is used to make sunburn products, soothing lotions, and aftershaves. The oil is astringent and is mainly used for its curative effects, especially in cases of acne and eczema. In folkloric medicine, birch bark extract was considered good for bathing skin eruptions. Destructive distillation of the bark’s white epidermis yields an empyreumatic oil known as oil of birch tar, Oleum rusci, or dagget. This is a thick, bituminous, brownish-black liquid with a pungent, balsamic odor. It contains a high percentage of methylsalicilate, creosol, and guaiacol and is almost identical to wintergreen oil.
Definition ChEBI: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.
Anticancer Research In addition, triterpenoids (betulin and its derivatives) isolated from HSSEactivated the signaling pathway regulated by p53 family genes, leading to the inhibition of BC cell viability or even the induction of apoptosis. And also, theseresearchers found that all the triterpenoids had no effect on normal breast cells.These findings provide an important basis for the use of those triterpenoids in thedevelopment of alternative therapies for breast cancer treatment (Hsu et al. 2015).
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