7-Hydroxycoumarin Basic information |
Product Name: | 7-Hydroxycoumarin |
Synonyms: | UMBELLIFERON;UMBELLIFERONE;7-HYDROXYCOUMARIN;7-Hydroxy-2H-1-benzopyran-2-one;3-BUTYLIDEN-4,5-DIHYDRO-3H-ISOBENZOFURAN-1-ONE;2H-1-BENZOPYRAN-2-ONE, 7-HYDROXY-;SKIMMETIN;Z-LIGUSTILIDE |
CAS: | 93-35-6 |
MF: | C9H6O3 |
MW: | 162.14 |
EINECS: | 202-240-3 |
Product Categories: | Coumarins;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;HU - HZEnvironmental Standards;MetabolitesFluorescent Probes, Labels, Particles and Stains;Alphabetic;Fluorescent Labels;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;H;Other Fluorescent Labels;Pesticides&Metabolites;Pharmaceutical intermediates;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;reagent;standard substance;Inhibitors;Coumarin;Fluorescent |
Mol File: | 93-35-6.mol |
7-Hydroxycoumarin Chemical Properties |
Melting point | 230 °C (dec.)(lit.) |
Boiling point | 248.82°C (rough estimate) |
density | 1.2599 (rough estimate) |
refractive index | 1.5380 (estimate) |
storage temp. | -20°C Freezer |
solubility | dioxane: soluble |
pka | 7.11(at 25℃) |
form | Powder and Agglomerate |
color | Off-white to beige-brownish |
PH Range | Non/ uorescence (6.5) to blue / uorescence (8.0) |
Water Solubility | 1 g/100 mL (100 ºC) |
λmax | 320nm |
Merck | 14,9847 |
BRN | 127683 |
Major Application | Fluorescent brighteners, fungicides, cosmetics, antitrypanosomal, antileishmanial activities, antifungal, antibacterial, antiinflammatory, antiHIV, detection of microorganisms, treatment of impaired neurotransmission disorders, Alzheimer’s disease, vascular and lymphatic edema cancer, early diagnosis of stroke, dental material, drug-coated coronary stent system |
InChIKey | ORHBXUUXSCNDEV-UHFFFAOYSA-N |
CAS DataBase Reference | 93-35-6(CAS DataBase Reference) |
NIST Chemistry Reference | 7-Hydroxycoumarin(93-35-6) |
EPA Substance Registry System | Umbelliferone (93-35-6) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
RTECS | GN6820000 |
HS Code | 29322980 |
Toxicity | LD50 intravenous in mouse: 450mg/kg |
MSDS Information |
Provider | Language |
---|---|
7-Hydroxycoumarin | English |
SigmaAldrich | English |
ACROS | English |
ALFA | English |
7-Hydroxycoumarin Usage And Synthesis |
Chemical Properties | Light Brownish Powder |
Uses | A metabolite of Coumarin. The aglucon of skimmin. Present in many plants |
Uses | antifungal, phytoalexin |
Uses | In sunscreen lotions and creams; as intracellular and pH sensitive fluorescent indicator and blood-brain barrier probe. |
Definition | ChEBI: A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7. |
Purification Methods | It crystallises from water (m 232-232.2o) or EtOH (m 232o). It sublimes at 160o/0.001mm. Fluorescence: Em max 452nm/Exc 325nm in 50% EtOH. [Beilstein 18 H 27, 18 I 306, 18 II 16, 18 III/IV 294, 18/1 V 386.] |
7-Hydroxycoumarin Preparation Products And Raw materials |