| Rutin Basic information |
| Product Name: | Rutin |
| Synonyms: | 3,3’,4’,5,7-pentahydroxy-flavon3-(o-rhamnosylglucoside);3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,74H-1-Benzopyran-4-one;3-[[6-O-(-Deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one;4-dihydroxyphenyl)-5,7-dihydroxy-yranosyl]oxy]-2-(;4h-1-benzopyran-4-one,3-[[6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucop;bioflavonoid;globularicitrin;ilixathin |
| CAS: | 153-18-4 |
| MF: | C27H30O16 |
| MW: | 610.52 |
| EINECS: | 205-814-1 |
| Product Categories: | TROXEPURE;Inhibitors;Biochemistry;Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals;Flavanols;Disaccharides;Flavonoids;Glycosides;Sugars;chemical reagent;pharmaceutical intermediate;ONGLYZA;reference substance;Aromatics;Heterocycles;Oligosaccharides;Plant extracts;Herb extract;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 153-18-4.mol |
| Rutin Chemical Properties |
| Melting point | 195 °C (dec.)(lit.) |
| alpha | D23 +13.82° (ethanol); D23 -39.43° (pyridine) |
| Boiling point | 576.13°C (rough estimate) |
| density | 1.3881 (rough estimate) |
| refractive index | 1.7650 (estimate) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | pyridine: 50 mg/mL |
| form | powder |
| pka | 6.17±0.40(Predicted) |
| Colour Index | 75730 |
| color | yellow to green |
| Water Solubility | 12.5 g/100 mL |
| Merck | 8304 |
| CAS DataBase Reference | 153-18-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Flavone-3-rutinoside, 3,3',4',5,7-pentahydroxy(153-18-4) |
| EPA Substance Registry System | Rutin (153-18-4) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 3 |
| RTECS | VM2975000 |
| F | 8 |
| HS Code | 29381000 |
| Toxicity | LD50 i.v. in mice: 950 mg/kg (propylene glycol soln) (Harrison) |
| MSDS Information |
| Provider | Language |
|---|---|
| Rutin sulfate | English |
| ACROS | English |
| Rutin Usage And Synthesis |
| Chemical Properties | Pale-Yellow Crystalline Solid |
| Uses | Found in many plants, especially the buckwheat plant. Identity with Ilixanthin. Capillary protectant. Rutin is colored brown by tobacco enzyme under experimental conditions. |
| Uses | antidiabetic, dipeptidyl peptidase–4 inhibitor |
| Uses | For nutritional product |
| Uses | rutin is described as helping to tighten and strengthen skin capillaries, and as such it could help prevent a couperose condition. It also demonstrates anti-oxidant properties. Rutin is a flavonoid found in rue leaves, buckwheat, and other plants. |
| Definition | ChEBI: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups. |
| Purification Methods | The vitamin crystallises from MeOH or water/EtOH, dry it in air, then dry it further for several hours at 110o or in high vacuum at 120o. It forms yellow crystals from EtOH/Me2CO/H2O (2:1:1). It has also been purified by passing (0.5g) through a Kieselgel column (30 x 5cm) with EtOAc/MeOH/H2O (100:20:15), and after 750mL have passed through, the yellow fraction of 250mL gives the glycoside (0.3g) on evaporation. [H.rhammer et al. Chem Ber 101 1183 1968, Marini-Bettòlo Gazz Chim Ital 80 631 1950, Beilstein 18/5 V 519.] |