Rutin Basic information |
Product Name: | Rutin |
Synonyms: | 3,3’,4’,5,7-pentahydroxy-flavon3-(o-rhamnosylglucoside);3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,74H-1-Benzopyran-4-one;3-[[6-O-(-Deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one;4-dihydroxyphenyl)-5,7-dihydroxy-yranosyl]oxy]-2-(;4h-1-benzopyran-4-one,3-[[6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucop;bioflavonoid;globularicitrin;ilixathin |
CAS: | 153-18-4 |
MF: | C27H30O16 |
MW: | 610.52 |
EINECS: | 205-814-1 |
Product Categories: | TROXEPURE;Inhibitors;Biochemistry;Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals;Flavanols;Disaccharides;Flavonoids;Glycosides;Sugars;chemical reagent;pharmaceutical intermediate;ONGLYZA;reference substance;Aromatics;Heterocycles;Oligosaccharides;Plant extracts;Herb extract;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
Mol File: | 153-18-4.mol |
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Rutin Chemical Properties |
Melting point | 195 °C (dec.)(lit.) |
alpha | D23 +13.82° (ethanol); D23 -39.43° (pyridine) |
Boiling point | 576.13°C (rough estimate) |
density | 1.3881 (rough estimate) |
refractive index | 1.7650 (estimate) |
storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
solubility | pyridine: 50 mg/mL |
form | powder |
pka | 6.17±0.40(Predicted) |
Colour Index | 75730 |
color | yellow to green |
Water Solubility | 12.5 g/100 mL |
Merck | 8304 |
CAS DataBase Reference | 153-18-4(CAS DataBase Reference) |
NIST Chemistry Reference | Flavone-3-rutinoside, 3,3',4',5,7-pentahydroxy(153-18-4) |
EPA Substance Registry System | Rutin (153-18-4) |
Safety Information |
Hazard Codes | Xn,Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 24/25-36-26 |
WGK Germany | 3 |
RTECS | VM2975000 |
F | 8 |
HS Code | 29381000 |
Toxicity | LD50 i.v. in mice: 950 mg/kg (propylene glycol soln) (Harrison) |
MSDS Information |
Provider | Language |
---|---|
Rutin sulfate | English |
ACROS | English |
Rutin Usage And Synthesis |
Chemical Properties | Pale-Yellow Crystalline Solid |
Uses | Found in many plants, especially the buckwheat plant. Identity with Ilixanthin. Capillary protectant. Rutin is colored brown by tobacco enzyme under experimental conditions. |
Uses | antidiabetic, dipeptidyl peptidase–4 inhibitor |
Uses | For nutritional product |
Uses | rutin is described as helping to tighten and strengthen skin capillaries, and as such it could help prevent a couperose condition. It also demonstrates anti-oxidant properties. Rutin is a flavonoid found in rue leaves, buckwheat, and other plants. |
Definition | ChEBI: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups. |
Purification Methods | The vitamin crystallises from MeOH or water/EtOH, dry it in air, then dry it further for several hours at 110o or in high vacuum at 120o. It forms yellow crystals from EtOH/Me2CO/H2O (2:1:1). It has also been purified by passing (0.5g) through a Kieselgel column (30 x 5cm) with EtOAc/MeOH/H2O (100:20:15), and after 750mL have passed through, the yellow fraction of 250mL gives the glycoside (0.3g) on evaporation. [H.rhammer et al. Chem Ber 101 1183 1968, Marini-Bettòlo Gazz Chim Ital 80 631 1950, Beilstein 18/5 V 519.] |