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China Northwest Factory Manufacturer L-CARNOSINE Cas 305-84-0 For stock delivery

China Northwest Factory Manufacturer L-CARNOSINE Cas 305-84-0 For stock delivery

  • Color
    White
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    Leader
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    USD300-500/KG
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Northwest Factory Manufacturer L-CARNOSINE Cas 305-84-0 For stock delivery

L-Carnosine Basic information
Description Reference
Product Name: L-Carnosine
Synonyms: N-B-ALANYL-L-HISTIDINE;H-BETA-ALA-HIS-OH;L-IGNOTINE;L-BETA-ALANINE HISTIDINE;L-CARNOSINE;B-ALANYL-L-HISTIDINE;BETA-A-H;BETA-ALANYL-L-HISTIDINE
CAS: 305-84-0
MF: C9H14N4O3
MW: 226.23
EINECS: 206-169-9
Product Categories: Food additive;amino;Amino Acids;chiral;Nutritional Supplements;API;Amino Acid Derivatives
Mol File: 305-84-0.mol
L-Carnosine Structure
 
L-Carnosine Chemical Properties
Melting point 253 °C (dec.)(lit.)
alpha 20.9 º (c=1.5, H2O)
Boiling point 367.84°C (rough estimate)
density 1.2673 (rough estimate)
refractive index 21 ° (C=2, H2O)
storage temp. 2-8°C
pka 2.62(at 25℃)
form crystalline
color White
Water Solubility almost transparency
Merck 14,1850
BRN 87671
Stability: Stable, but may be heat sensitive - store cold. Incompatible with strong oxidizing agents.
InChIKey CQOVPNPJLQNMDC-ZETCQYMHSA-N
CAS DataBase Reference 305-84-0(CAS DataBase Reference)
EPA Substance Registry System L-Histidine, .beta.-alanyl- (305-84-0)
 
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 24/25-36-26
WGK Germany 2
RTECS MS3080000
F 3-10
TSCA Yes
HS Code 29332900
Toxicity LD50 oral in mouse: > 14930mg/kg
MSDS Information
Provider Language
L-Carnosine English
SigmaAldrich English
ACROS English
 
L-Carnosine Usage And Synthesis
Description Carnosine is a dipeptide comprising beta-alanine and histidine. It is found in muscular and other tissues. It has strong oxidant property as it can scavenge both reactive oxygen species (ROS) and reactive nitrogen species (RNS). Carnosine acts as a cytosolic buffering agent and as a regulator of macrophage function.1 Attributing to its ability to form complexes with transition metals, it is used to regulate the content of transition metal ions in biological fluids and tissues.
Carnosine can prevent aging and can be used to prevent or treat complications of diabetes such as nerve damage, eye disorders (cataracts), and kidney problems.2 Potential therapeutic actions of carnosine include antihypertensive effects, immunomodulation, would healing, and antitumor/chemopreventive effects. The chelate compound of zinc ion and carnosine has been used in Japan for gastritis, gastric ulcers, and dyspepsia symptoms.3
Reference
  1. P. J. Quinn, A. A. Boldyrev, V. E. Formazuyk, Carnosine: Its properties, functions and potential therapeutic applications, Molecular Aspects of Medicine, 1992, vol. 13, pp. 379-444
  2. https://www.webmd.com/vitamins/ai/ingredientmono-1038/carnosine
  3. G. M. Halpern, Zinc-Carnosine: Nature’s Safe and Effective Remedy for Ulcers, 2005, ISBN-10 0757002749
Chemical Properties Crystalline
Uses antioxidant, antisenescense, antineoplastic
Uses L-Carnosine is a naturally-occurring histidine-containing compound and the biological role of this dipeptide is to act as cytosolic buffering agents. Other roles ascribed to L-Carnosine include action s as neurotransmitters, modulation of enzymic activities and chelation of heavy metals.
Uses carnosine is an anti-oxidant that works to prevent cellular damage because of free radical activity. Studies indicate an ability to boost the immunological functions. Carnosine is a naturally occurring amino acid. In cosmetics, it has anti-aging and skin-conditioning applications.
Definition ChEBI: A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.
Synthesis Reference(s) The Journal of Organic Chemistry, 48, p. 392, 1983 DOI: 10.1021/jo00151a026
Safety Profile Mildly toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods Likely impurities are histidine and β-alanine. Crystallise L-carnosine from water by adding EtOH in excess. Recrystallise it from aqueous EtOH by slow addition of EtOH to a strong aqueous solution of the dipeptide. Its solubility in H2O is 33.3% at 25o. [Vinick & Jung J Org Chem 48 392 1983, Turner J Am Chem Soc 75 2388 1953, Sifford & du Vigneaud J Biol Chem 108 753 1935, Beilstein 25 H 516, 25 I 717, 25 II 408.]