China Northwest Factory Manufacturer Piroctone Olamine Cas 68890-66-4 For stock delivery

Piroctone olamine (INN; also known as piroctone ethanolamine; brand name Octopirox) is a compound sometimes used in the treatment of fungal infections.Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.

White or slightly yellow crystalline powder.

Freely soluble in 10% ethanol in water; soluble in solution containing surfactants in water or in 1%-10% ethanol; slightly soluble in water and in oil. The solubility in water varies by pH value, and is a litter larger in neutral or weak basic solution than in acid solution.

Acute toxicity : Acute oral LD50 –rat 8100mg/kg, practically nontoxic.

Subchronic toxicity : NOEL: 100mg//kg/d (rat, orally, 3 months).

Chronic toxicity and carcinogencity : Negative.

Mutagenicity : Negative.

Irritation to skin and eye : Very low.

Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.