Brand Name: | Leader |
Model Number: | LD |
MOQ: | 25KGS |
Price: | US1500-2000KG |
Payment Terms: | Western Union, MoneyGram, T/T, L/C |
Supply Ability: | 10MTS/Month |
Fusidine Usage And Synthesis |
Mode of action | Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site. Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci. |
Chemical Properties | White Solid |
Uses | Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. |
Uses | antibacterial |
Definition | ChEBI: A antibiotic that is isolated from the fermentation broth of Fusidium coccineum. |
Brand name | Fucidine (Bristol-Myers Squibb). |
Hazard | Moderately toxic inhibitor of translocation during protein synthesis. |