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| Potassium orotate Basic information |
| Product Name: | Potassium orotate |
| Synonyms: | OROTIC ACID MONOPOTASSIUM SALT;OROTIC ACID POTASSIUM SALT;POTASSIUM OROTATE;1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicacimonopotassiumsal;1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicacimonopotassiumsalt;ba2658;dioron;6-CARBOXY-2,4-DIHYDROXYPYRIMIDINE MONOPOTASSIUM SALT |
| CAS: | 24598-73-0 |
| MF: | C5H3KN2O4 |
| MW: | 194.19 |
| EINECS: | 246-341-0 |
| Product Categories: | Fine Chemical |
| Mol File: | 24598-73-0.mol |
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| Potassium orotate Chemical Properties |
| Melting point | >300°C |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Aqueous Base (Slightly) |
| form | Solid |
| color | White to Light Yellow |
| Stability: | Hygroscopic |
| LogP | -0.928 (est) |
| CAS DataBase Reference | 24598-73-0(CAS DataBase Reference) |
| EPA Substance Registry System | 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, monopotassium salt (24598-73-0) |
| Safety Information |
| WGK Germany | 2 |
| RTECS | RM3201500 |
| HazardClass | IRRITANT |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Potassium orotate Usage And Synthesis |
| Uses | Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis. |
